Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dalfampridine
Drug ID BADD_D00574
Description Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. This is the first drug that was specifically approved to help with mobility in these patients. FDA approved on January 22, 2010.
Indications and Usage Dalfampridine is a neurofunctional modifier that helps improve walking speed in patients with multiple sclerosis (MS).
Marketing Status Prescription
ATC Code N07XX07
DrugBank ID DB06637
KEGG ID D04127
MeSH ID D015761
PubChem ID 1727
TTD Drug ID D08YIN
NDC Product Code 38779-3205; 42571-338; 63190-0510; 46016-5042; 16729-292; 56125-427; 62756-429; 0054-0479; 42571-275; 51927-5030; 12817-054; 54382-125; 62756-038; 63190-0530; 51407-246; 65862-917; 65372-1157; 65862-863; 62991-3143; 67877-444; 10144-427; 0378-0509
Synonyms 4-Aminopyridine | 4 Aminopyridine | Dalfampridine | Pymadine | VMI-103 | VMI 103 | VMI103 | 4-Aminopyridine Sustained Release | 4 Aminopyridine Sustained Release | Sustained Release, 4-Aminopyridine | Fampridine-SR | Fampridine SR
Chemical Information
Molecular Formula C5H6N2
CAS Registry Number 504-24-5
SMILES C1=CN=CC=C1N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Influenza like illness08.01.03.0100.035293%
Ingrowing nail23.02.05.0110.002614%Not Available
Inguinal hernia07.16.02.0010.002614%Not Available
Initial insomnia19.02.01.005; 17.15.03.0050.003921%Not Available
Insomnia19.02.01.002; 17.15.03.0020.186925%
Intestinal obstruction07.13.01.002--Not Available
Irritability08.01.03.011; 19.04.02.013--
Joint dislocation15.01.07.002; 12.04.02.0070.002614%Not Available
Joint stiffness15.01.02.003--Not Available
Joint swelling15.01.02.004--Not Available
Kidney infection20.01.09.004; 11.01.14.0060.007843%
Laboratory test abnormal13.18.01.0010.461429%Not Available
Laceration12.01.06.006; 23.03.11.0040.022222%Not Available
Lactose intolerance14.02.02.001; 07.17.01.0030.002614%Not Available
Laryngeal pain22.02.05.036--
Laryngitis11.01.13.001; 22.07.03.0010.003921%
Lethargy17.02.04.003; 08.01.01.008; 19.04.04.004--
Ligament sprain15.07.02.004; 12.01.07.0080.007843%Not Available
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.005--Not Available
Liver disorder09.01.08.001--Not Available
Liver function test abnormal13.03.01.0130.011764%Not Available
Local swelling08.01.03.0130.015686%Not Available
Loss of consciousness17.02.04.004--Not Available
Loss of control of legs08.01.02.0030.003921%Not Available
Low density lipoprotein increased13.12.01.0050.009150%Not Available
Lymphadenopathy01.09.01.002--Not Available
Lymphocyte count abnormal13.01.06.0220.005229%Not Available
Lymphocyte count decreased13.01.06.0060.028758%
Lymphocyte count increased13.01.06.0070.005229%
Lymphoedema24.09.01.001; 01.09.01.0060.002614%
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