Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cytarabine
Drug ID BADD_D00560
Description A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Indications and Usage For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia.
Marketing Status Prescription; Discontinued
ATC Code L01BC01
DrugBank ID DB00987
KEGG ID D00168
MeSH ID D003561
PubChem ID 6253
TTD Drug ID D07XSN
NDC Product Code 67457-452; 68083-343; 58623-0026; 68083-337; 67457-455; 71288-108; 61703-303; 70516-0163; 71288-109; 61703-319; 63323-120; 71288-169; 61703-305; 71288-168; 55512-0026; 61703-304; 12848-1003
Synonyms Cytarabine | Arabinosylcytosine | Cytosine Arabinoside | Arabinoside, Cytosine | Arabinofuranosylcytosine | Aracytidine | beta-Ara C | beta Ara C | Cytarabine Hydrochloride | Cytosar | Cytosar-U | Cytosar U | Ara-C | Ara C | Aracytine | Cytonal
Chemical Information
Molecular Formula C9H13N3O5
CAS Registry Number 147-94-4
SMILES C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Jaundice09.01.01.004; 01.06.04.004; 23.03.03.0300.001066%Not Available
Lactic acidosis14.01.01.002--Not Available
Lethargy17.02.04.003; 08.01.01.008; 19.04.04.004--
Leukocytosis01.02.01.0020.001598%
Leukoencephalopathy17.13.02.0030.000278%
Leukopenia01.02.02.0010.001332%Not Available
Lipase increased13.05.01.0030.000533%
Liver abscess11.01.18.001; 09.01.11.0010.000799%Not Available
Liver function test abnormal13.03.01.0130.000799%Not Available
Local swelling08.01.03.0130.000533%Not Available
Loss of consciousness17.02.04.004--Not Available
Lung consolidation22.01.02.0100.001865%Not Available
Lung disorder22.02.07.0010.001865%Not Available
Lung infiltration22.01.02.0040.001598%Not Available
Lymphadenitis01.09.01.0010.001066%Not Available
Lymphadenopathy01.09.01.0020.000799%Not Available
Maculopathy06.09.03.0070.000533%Not Available
Malaise08.01.01.003--
Melaena24.07.02.013; 07.12.02.0040.000533%Not Available
Meningitis17.06.03.001; 11.01.03.0010.000533%
Menorrhagia21.01.03.0020.000799%
Metabolic acidosis14.01.01.0030.002398%Not Available
Mouth ulceration07.05.06.0040.000533%Not Available
Movement disorder17.01.02.0100.000533%Not Available
Mucormycosis22.07.03.021; 11.03.05.011; 07.05.07.011; 17.06.09.0030.000625%Not Available
Mucosal inflammation08.01.06.0020.007992%Not Available
Mucous membrane disorder08.01.06.0040.000533%Not Available
Muscle necrosis15.05.05.0070.000533%Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.007--
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