Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cytarabine
Drug ID BADD_D00560
Description A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Indications and Usage For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia.
Marketing Status Prescription; Discontinued
ATC Code L01BC01
DrugBank ID DB00987
KEGG ID D00168
MeSH ID D003561
PubChem ID 6253
TTD Drug ID D07XSN
NDC Product Code 67457-452; 68083-343; 58623-0026; 68083-337; 67457-455; 71288-108; 61703-303; 70516-0163; 71288-109; 61703-319; 63323-120; 71288-169; 61703-305; 71288-168; 55512-0026; 61703-304; 12848-1003
Synonyms Cytarabine | Arabinosylcytosine | Cytosine Arabinoside | Arabinoside, Cytosine | Arabinofuranosylcytosine | Aracytidine | beta-Ara C | beta Ara C | Cytarabine Hydrochloride | Cytosar | Cytosar-U | Cytosar U | Ara-C | Ara C | Aracytine | Cytonal
Chemical Information
Molecular Formula C9H13N3O5
CAS Registry Number 147-94-4
SMILES C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardiomyopathy02.04.01.0010.001598%Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.0010.000139%Not Available
Cellulitis23.09.01.001; 11.02.01.0010.001865%Not Available
Cerebellar syndrome17.02.02.0020.001066%Not Available
Cerebral atrophy17.11.01.0010.000533%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.0030.000486%Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills08.01.09.001; 15.05.03.0160.003996%
Cholecystitis09.03.01.0010.003197%
Cholelithiasis09.03.01.0020.001066%Not Available
Cholestasis09.01.01.0010.001332%Not Available
Circulatory collapse24.06.02.0010.000347%Not Available
Clostridium difficile colitis11.02.02.004; 07.19.01.0040.002398%Not Available
Coagulopathy01.01.02.0010.001332%Not Available
Colitis07.08.01.0010.008259%
Coma17.02.09.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis06.04.01.002; 11.01.06.012--
Constipation07.02.02.001--
Cough22.02.03.001--
Croup infectious22.07.03.023; 11.01.13.0200.000139%Not Available
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.0020.000533%
Death08.04.01.001--
Dehydration14.05.05.001--
Depressed level of consciousness17.02.04.0020.002398%
Dermatitis bullous23.03.01.0020.000533%
Diarrhoea07.02.01.001--
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