Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cytarabine
Drug ID BADD_D00560
Description A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Indications and Usage For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia.
Marketing Status Prescription; Discontinued
ATC Code L01BC01
DrugBank ID DB00987
KEGG ID D00168
MeSH ID D003561
PubChem ID 6253
NDC Product Code 67457-452; 68083-343; 58623-0026; 68083-337; 67457-455; 71288-108; 61703-303; 70516-0163; 71288-109; 61703-319; 63323-120; 71288-169; 61703-305; 71288-168; 55512-0026; 61703-304; 12848-1003
Synonyms Cytarabine | Arabinosylcytosine | Cytosine Arabinoside | Arabinoside, Cytosine | Arabinofuranosylcytosine | Aracytidine | beta-Ara C | beta Ara C | Cytarabine Hydrochloride | Cytosar | Cytosar-U | Cytosar U | Ara-C | Ara C | Aracytine | Cytonal
Chemical Information
Molecular Formula C9H13N3O5
CAS Registry Number 147-94-4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal adhesions12.02.03.006; Available
Abdominal distension07.01.04.0010.001332%
Abdominal pain07.01.05.0020.005062%
Abdominal pain upper07.01.05.003--
Abdominal tenderness07.01.05.0040.000533%Not Available
Abscess11.01.08.0010.001066%Not Available
Acute febrile neutrophilic dermatosis23.03.03.033; Available
Acute hepatic failure09.01.03.0010.000486%Not Available
Acute leukaemia01.10.02.001; Available
Acute myeloid leukaemia16.01.05.001; Available
Acute myocardial infarction02.02.02.001; Available
Acute respiratory distress syndrome22.01.03.0010.002363%
Acute respiratory failure22.02.06.001; Available
Adrenal insufficiency05.01.02.001;
Agranulocytosis01.02.03.0010.001332%Not Available
Alanine aminotransferase increased13.03.01.003--
Anaemia megaloblastic14.12.01.003; Available
Anal fistula07.11.05.0020.000799%
Anaphylactic reaction24.06.03.006;
Angina pectoris24.04.04.002;
Anuria20.01.03.0020.000533%Not Available
Aplasia03.02.01.002; Available
Arrhythmia02.03.02.0010.000799%Not Available
Arteriosclerosis coronary artery24.04.04.012; Available
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