Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Crizotinib
Drug ID BADD_D00535
Description Crizotinib an inhibitor of receptor tyrosine kinase for the treatment of non-small cell lung cancer (NSCLC). Verification of the presence of ALK fusion gene is done by Abbott Molecular's Vysis ALK Break Apart FISH Probe Kit. This verification is used to select for patients suitable for treatment. FDA approved in August 26, 2011.
Indications and Usage Crizotinib is used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) that is anaplastic-lymphoma kinase (ALK)-positive as detected by a FDA-approved test.
Marketing Status Prescription
ATC Code L01ED01
DrugBank ID DB08865
KEGG ID D09731
MeSH ID D000077547
PubChem ID 11626560
TTD Drug ID D03ZBT
NDC Product Code 0069-8141; 53869-2231; 68724-1020; 0069-8140; 72969-115; 53869-2230
Synonyms Crizotinib | PF-02341066 | PF-2341066 | PF 2341066 | PF2341066 | PF 02341066 | PF02341066 | Xalkori
Chemical Information
Molecular Formula C21H22Cl2FN5O
CAS Registry Number 877399-52-5
SMILES CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Arthralgia15.01.02.001--
Ascites02.05.04.002; 09.01.05.003; 07.07.01.001--
Aspartate aminotransferase increased13.03.01.0060.013321%
Aspiration22.02.07.0070.000208%
Asthenia08.01.01.0010.019714%Not Available
Asthenopia06.01.01.0020.000533%Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atelectasis22.01.02.0010.000533%
Atrial fibrillation02.03.03.002--
Atrial flutter02.03.03.0030.000533%
Back pain15.03.04.005--
Blindness17.17.01.003; 06.02.02.0010.003197%Not Available
Blindness transient17.17.01.004; 06.02.02.0020.000533%Not Available
Blood albumin decreased13.09.01.0010.002131%Not Available
Blood bilirubin increased13.03.01.0080.003996%
Blood creatine increased13.13.01.0010.000533%Not Available
Blood creatine phosphokinase increased13.04.01.0010.004795%
Blood creatinine increased13.13.01.0040.009324%
Blood glucose decreased13.02.02.001--Not Available
Blood glucose increased13.02.02.002--Not Available
Blood lactate dehydrogenase increased13.04.02.0020.001598%
Blood potassium decreased13.11.01.0100.001865%Not Available
Blood pressure decreased13.14.03.002--Not Available
Blood pressure increased13.14.03.005--Not Available
Blood sodium decreased13.11.01.0120.001332%Not Available
Blood testosterone decreased13.10.05.0040.001598%Not Available
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.0040.000799%Not Available
Bone pain15.02.01.001--
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