Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cocaine hydrochloride
Drug ID BADD_D00515
Description An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Indications and Usage For the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.
Marketing Status approved; illicit
ATC Code S01HA01; N01BC01; S02DA02; R02AD03
DrugBank ID DB00907
KEGG ID D02182
MeSH ID D003042
PubChem ID 656832
TTD Drug ID D04XPW
NDC Product Code 64950-362; 38779-0723; 51552-0881; 49452-2177; 64950-359; 61960-9041; 0406-1520; 51927-9011
UNII XH8T8T6WZH
Synonyms Cocaine | Cocaine Hydrochloride | Hydrochloride, Cocaine | Cocaine HCl | HCl, Cocaine
Chemical Information
Molecular Formula C17H22ClNO4
CAS Registry Number 53-21-4
SMILES CN1C2CCC1C(C(C2)OC(=O)C3=CC=CC=C3)C(=O)OC.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Corneal epithelium defect06.06.03.012---
Death08.04.01.001--
Depression19.15.01.001--
Generalised tonic-clonic seizure17.12.01.002---
Mydriasis17.02.11.003; 06.05.03.004---
Nail pitting23.02.05.012---
Nervousness19.06.02.003---
Respiratory failure22.02.06.002; 14.01.04.003--
Restlessness19.11.02.002; 17.02.05.021--
Tremor17.01.06.002--
Vasoconstriction23.06.05.007; 24.04.03.008---
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Central nervous system stimulation25.04.01.001---
Ulcerative keratitis10.02.01.021; 06.04.02.004--
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