Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cocaine hydrochloride
Drug ID BADD_D00515
Description An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Indications and Usage For the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.
Marketing Status Prescription
ATC Code N01BC01; R02AD03; S01HA01; S02DA02
DrugBank ID DB00907
KEGG ID D02182
MeSH ID D003042
PubChem ID 656832
NDC Product Code 49452-2177; 64950-362; 51552-0881; 61960-9041; 64950-359; 0406-1520; 38779-0723; 51927-9011
Synonyms Cocaine | Cocaine Hydrochloride | Hydrochloride, Cocaine | Cocaine HCl | HCl, Cocaine
Chemical Information
Molecular Formula C17H22ClNO4
CAS Registry Number 53-21-4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HyperphosphatasaemiaAlanine aminotransferase 1P24298Not AvailableNot Available
Liver injuryAlanine aminotransferase 1P24298Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Corneal epithelium defect06.06.03.012--Not Available
Generalised tonic-clonic seizure17.12.01.002--Not Available
Mydriasis06.05.03.004; Available
Nail pitting23.02.05.012--Not Available
Nervousness19.06.02.003--Not Available
Respiratory failure22.02.06.002;
Vasoconstriction24.04.03.008; Available
Vision blurred17.17.01.010;
Central nervous system stimulation25.04.01.001--Not Available
Ulcerative keratitis10.02.01.021;
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