Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status Prescription; Discontinued
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 57664-345; 0904-7088; 16729-141; 71554-025; 0093-3086; 51079-921; 55154-3568; 60687-404; 0378-3815; 51407-086; 0093-3087; 52817-601; 76072-1010; 0378-0972; 60687-548; 51862-274; 60429-989; 64374-004; 70518-3391; 12828-0072; 0378-0825; 60687-415; 53296-0033; 65862-846; 57664-241; 55154-8285; 57664-347; 65015-706; 60429-990; 51862-901; 0378-3813; 51407-085; 63552-062; 63629-2360; 69809-0126; 60687-426; 63629-2361; 72721-1725; 72721-1760; 0093-4404; 0904-7089; 67835-0028; 65862-847; 16729-142; 0378-0860; 57664-211; 51862-903; 0093-7772; 51862-273; 65862-844; 51079-749; 51079-922; 0093-5377; 0904-7087; 63629-2362; 65862-845; 70518-3357; 63552-063; 0093-5416; 69809-0130; 72721-1750; 51079-288; 72721-1770; 0093-4359; 0093-5419; 69809-0127; 0093-5376; 69809-0135; 63629-2359; 0378-0973; 73377-150; 51862-902; 0093-5417; 0093-4405; 51862-900
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Tardive dyskinesiaD(4) dopamine receptorP21917T2498310821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesiaD(2) dopamine receptorP14416T6716210821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesiaD(3) dopamine receptorP35462T0255110821369; 10379516; 10893495; 9777180; 10889553
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Aphonia22.02.05.024; 19.19.01.002; 17.02.08.009--
Aplastic anaemia01.03.03.002--Not Available
Apnoea22.02.01.001--
Appendicitis11.01.07.001; 07.19.01.0010.086874%
Apraxia17.02.03.002; 19.21.01.0020.011210%Not Available
Areflexia17.02.01.001--Not Available
Arrhythmia02.03.02.001--Not Available
Arteriosclerosis24.04.02.001--Not Available
Arteriosclerosis coronary artery24.04.04.012; 02.02.01.0110.007311%Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Arthropathy15.01.01.003--Not Available
Ascites07.07.01.001; 02.05.04.002; 09.01.05.003--
Aspartate aminotransferase increased13.03.01.006--
Asphyxia22.02.02.001; 12.01.08.0110.008042%Not Available
Aspiration22.02.07.0070.030705%
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.0100.170946%Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atelectasis22.01.02.0010.019617%
Atrial fibrillation02.03.03.002--
Atrial flutter02.03.03.003--
Atrial septal defect03.07.02.002; 02.04.02.009--Not Available
Atrioventricular block02.03.01.002--Not Available
Atrioventricular block complete02.03.01.0030.033629%
Atrioventricular block first degree02.03.01.0040.028024%
Atrioventricular block second degree02.03.01.005--
Atypical pneumonia22.07.01.010; 11.01.09.0120.008407%Not Available
Aura17.02.07.0110.005605%Not Available
Autism19.22.02.001; 17.03.05.0010.008407%Not Available
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