ADReCS

Pharmaceutical Information

Drug Name	Clozapine
Drug ID	BADD_D00511
Description	A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage	For use in patients with treatment-resistant schizophrenia.
Marketing Status	Prescription; Discontinued
ATC Code	N05AH02
DrugBank ID	DB00363
KEGG ID	D00283
MeSH ID	D003024
PubChem ID	135398737
TTD Drug ID	D0Z1RV
NDC Product Code	57664-345; 0904-7088; 16729-141; 71554-025; 0093-3086; 51079-921; 55154-3568; 60687-404; 0378-3815; 51407-086; 0093-3087; 52817-601; 76072-1010; 0378-0972; 60687-548; 51862-274; 60429-989; 64374-004; 70518-3391; 12828-0072; 0378-0825; 60687-415; 53296-0033; 65862-846; 57664-241; 55154-8285; 57664-347; 65015-706; 60429-990; 51862-901; 0378-3813; 51407-085; 63552-062; 63629-2360; 69809-0126; 60687-426; 63629-2361; 72721-1725; 72721-1760; 0093-4404; 0904-7089; 67835-0028; 65862-847; 16729-142; 0378-0860; 57664-211; 51862-903; 0093-7772; 51862-273; 65862-844; 51079-749; 51079-922; 0093-5377; 0904-7087; 63629-2362; 65862-845; 70518-3357; 63552-063; 0093-5416; 69809-0130; 72721-1750; 51079-288; 72721-1770; 0093-4359; 0093-5419; 69809-0127; 0093-5376; 69809-0135; 63629-2359; 0378-0973; 73377-150; 51862-902; 0093-5417; 0093-4405; 51862-900
Synonyms	Clozapine \| Clozaril \| Leponex

Chemical Information

Molecular Formula	C18H19ClN4
CAS Registry Number	5786-21-0
SMILES	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure

ADR Related Proteins Induced by Drug

ADR Term	Protein Name	UniProt AC	TTD Target ID	PMID
Tardive dyskinesia	D(4) dopamine receptor	P21917	T24983	10821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesia	D(2) dopamine receptor	P14416	T67162	10821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesia	D(3) dopamine receptor	P35462	T02551	10821369; 10379516; 10893495; 9777180; 10889553

ADRs Induced by Drug

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Femoral neck fracture	15.08.03.002; 12.04.01.002	0.019617%		Not Available
Femur fracture	15.08.03.003; 12.04.01.003	-	-	Not Available
Fibrin D dimer increased	13.01.02.036	0.014012%		Not Available
Flat affect	19.04.01.004	0.011210%		Not Available
Flatulence	07.01.04.002	-	-
Fluid retention	20.01.02.003; 14.05.06.002	-	-	Not Available
Folliculitis	23.09.04.007; 11.01.12.018	-	-
Food poisoning	07.11.01.007; 12.03.01.024; 11.07.02.001	0.016814%		Not Available
Foot fracture	15.08.03.012; 12.04.01.012	-	-	Not Available
Fracture	15.08.02.001; 12.04.02.001	-	-
Fungal infection	11.03.05.001	-	-	Not Available
Gait disturbance	17.02.05.016; 08.01.02.002	-	-
Gallbladder disorder	09.03.02.001	-	-	Not Available
Gamma-glutamyltransferase increased	13.03.01.011	0.089677%
Gangrene	24.04.05.003; 23.06.06.001; 11.02.01.003	-	-	Not Available
Gastric cancer	16.13.03.001; 07.21.02.001	0.010235%		Not Available
Gastric dilatation	07.02.02.002	0.002924%		Not Available
Gastric haemorrhage	24.07.02.007; 07.12.01.001	-	-
Gastric ulcer	07.04.03.002	-	-
Gastritis	07.08.02.001	-	-
Gastrooesophageal reflux disease	07.02.02.003	-	-
Gastroenteritis	11.01.07.004; 07.19.03.001	0.064455%		Not Available
Gastroenteritis viral	11.05.04.005; 07.19.03.005	-	-	Not Available
Gastrointestinal carcinoma	16.13.04.001; 07.21.03.001	0.016814%		Not Available
Gastrointestinal disorder	07.11.01.001	-	-	Not Available
Gastrointestinal haemorrhage	24.07.02.009; 07.12.02.001	-	-	Not Available
Gastrointestinal infection	11.01.07.012; 07.19.02.005	0.016814%		Not Available
Gastrointestinal necrosis	24.04.08.006; 07.15.01.003	-	-
Generalised anxiety disorder	19.06.01.004	0.005605%		Not Available
Generalised oedema	14.05.06.007; 08.01.07.004	-	-

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