Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clorazepic acid
Drug ID BADD_D00507
Description A water-soluble benzodiazepine derivative effective in the treatment of anxiety. It has also muscle relaxant and anticonvulsant actions.
Indications and Usage For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Also used as adjunctive therapy in the management of partial seizures and for the symptomatic relief of acute alcohol withdrawal.
Marketing Status Prescription; Discontinued
ATC Code N05BA05
DrugBank ID DB00628
KEGG ID D00694
MeSH ID D003009
PubChem ID 2809
TTD Drug ID D0P3JU
NDC Product Code Not Available
Synonyms Clorazepate Dipotassium | Dipotassium Chlorazepate | 4306-CB | Chlorazepate | Clorazepate | Tranxene | Tranxilium | Clorazepic Acid | Clorazepate Monopotassium
Chemical Information
Molecular Formula C16H11ClN2O3
CAS Registry Number 23887-31-2
SMILES C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaemia01.03.02.0010.007077%
Asthenia08.01.01.001--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Blood pressure systolic decreased13.14.03.007--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.001231%Not Available
Cholelithiasis09.03.01.0020.004718%Not Available
Colitis ischaemic24.04.08.012; 07.08.01.0040.007077%Not Available
Coma17.02.09.0010.016514%Not Available
Confusional state19.13.01.001; 17.02.03.0050.004718%
Dehydration14.05.05.0010.004718%
Dermatitis23.03.04.002--Not Available
Diplopia17.17.01.005; 06.02.06.002--Not Available
Disturbance in attention19.21.02.002; 17.03.03.0010.007077%
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.0070.007077%
Drug abuse19.07.02.0100.011795%Not Available
Drug dependence19.07.02.0090.004718%Not Available
Dry mouth07.06.01.002--
Dysarthria19.19.03.001; 17.02.08.001--
Dystonia17.01.03.0010.004718%Not Available
Electrocardiogram QT prolonged13.14.05.0040.001231%
Eosinophilia01.02.04.0010.004718%
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Haematocrit decreased13.01.05.001--Not Available
Headache17.14.01.0010.007077%
Hyperkalaemia14.05.03.0010.007077%
Hyperthermia12.05.01.002; 08.05.01.0010.004718%Not Available
Hypotension24.06.03.0020.007077%
Hypothermia12.05.03.001; 08.05.01.0030.004718%
Insomnia19.02.01.002; 17.15.03.002--
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