ADReCS

Pharmaceutical Information

Drug Name	Clopidogrel
Drug ID	BADD_D00504
Description	Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213] It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin.[A180547] Clopidogrel was granted FDA approval on 17 November 1997.[L7213]
Indications and Usage	Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213]
Marketing Status	approved
ATC Code	B01AC04
DrugBank ID	DB00758
KEGG ID	D07729; D10823; D10824
MeSH ID	D000077144
PubChem ID	60606
TTD Drug ID	D0N0TZ
NDC Product Code	42543-714; 50090-4918; 52605-083; 16729-218; 0024-1171; 68788-8190; 72578-012; 65977-0037; 52605-082; 63187-362; 63629-4728; 70518-0400; 33342-060; 42543-713; 65162-414; 0093-7314; 16729-219; 61919-007; 67296-1840; 50090-2598; 50090-5781; 0024-1332; 61919-737; 70771-1062; 16714-052; 68071-2813; 68071-4138; 71335-0581
UNII	A74586SNO7
Synonyms	Clopidogrel \| SC 25989C \| SC 25990C \| SR 25989 \| Clopidogrel-Mepha \| Clopidogrel Mepha \| Clopidogrel Sandoz \| Iscover \| Clopidogrel Napadisilate \| Clopidogrel Hydrochloride \| PCR 4099 \| PCR-4099 \| Clopidogrel Besylate \| Clopidogrel Besilate \| Clopidogrel, (+)(S)-isomer \| Plavix \| Clopidogrel Bisulfate

Chemical Information

Molecular Formula	C16H16ClNO2S
CAS Registry Number	113665-84-2
SMILES	COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Gastrointestinal haemorrhage	07.12.02.001; 24.07.02.009	0.001985%		Not Available
Gastrointestinal necrosis	24.04.08.006; 07.15.01.003	0.000128%
Gastrointestinal pain	07.01.05.005	-	-
Gastrointestinal perforation	07.04.04.001	0.000021%		Not Available
Generalised oedema	14.05.06.007; 08.01.07.004	0.000053%
Generalised tonic-clonic seizure	17.12.01.002	-	-	Not Available
Gingival bleeding	24.07.02.010; 07.09.07.001	0.000280%		Not Available
Glomerulonephritis	20.05.01.001; 10.02.01.006	0.000021%		Not Available
Glomerulonephritis membranous	20.05.01.007	0.000021%		Not Available
Glossitis	07.14.01.001	0.000021%		Not Available
Glucose-6-phosphate dehydrogenase deficiency	03.08.03.001; 01.06.05.001; 14.14.03.001	-	-	Not Available
Gout	15.01.06.001; 14.09.01.001	-	-	Not Available
Granulocytopenia	01.02.03.003	0.000043%		Not Available
Gravitational oedema	08.01.07.005; 02.05.04.014	-	-	Not Available
Gynaecomastia	21.05.04.003; 05.05.02.003	0.000143%
Haemangioma of liver	16.06.01.003; 24.03.06.006; 09.04.01.003	0.000021%		Not Available
Haemarthrosis	24.07.01.046; 15.01.01.004; 12.04.03.001	0.000128%		Not Available
Haematemesis	24.07.02.011; 07.12.02.002	0.000898%		Not Available
Haematochezia	07.12.02.003; 24.07.02.012	0.000593%		Not Available
Haematoma	24.07.01.001	0.001037%
Haematospermia	21.03.03.003; 24.07.03.008	0.000064%		Not Available
Haematuria	21.10.01.018; 24.07.01.047; 20.02.01.006	0.000896%
Haemoglobin	13.01.05.018	-	-	Not Available
Haemoglobin decreased	13.01.05.003	-	-	Not Available
Haemolysis	01.06.04.002	0.000021%
Haemolytic anaemia	01.06.03.002	0.000139%		Not Available
Haemolytic uraemic syndrome	20.01.03.011; 01.06.02.001	0.000086%
Haemoptysis	24.07.01.006; 22.02.03.004; 02.11.04.009	0.000727%		Not Available
Haemorrhage intracranial	24.07.04.003; 17.08.01.008	0.000667%
Haemorrhage subcutaneous	24.07.06.010; 23.06.07.002	0.000182%		Not Available

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