Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clopidogrel
Drug ID BADD_D00504
Description Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213] It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin.[A180547] Clopidogrel was granted FDA approval on 17 November 1997.[L7213]
Indications and Usage For the reduction of atherosclerotic events (myocardial infarction, stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease.
Marketing Status Prescription; Discontinued
ATC Code B01AC04
DrugBank ID DB00758
KEGG ID D07729
MeSH ID D000077144
PubChem ID 60606
TTD Drug ID D0N0TZ
NDC Product Code 65977-0037; 0093-7314; 16729-218; 42543-713; 71335-1409; 42543-714; 65162-414; 68788-7645; 52605-083; 50090-5781; 50090-4918; 70518-0400; 61919-737; 52605-082; 63653-1171; 0024-1332; 63187-362; 70934-708; 61919-007; 33342-060; 68071-1578; 70771-1062; 68071-4138; 71335-0581; 63629-4728; 16729-219; 63653-1332; 0024-1171; 72578-012
Synonyms Clopidogrel | SC 25989C | SC 25990C | SR 25989 | Clopidogrel-Mepha | Clopidogrel Mepha | Clopidogrel Sandoz | Iscover | Clopidogrel Napadisilate | Clopidogrel Hydrochloride | PCR 4099 | PCR-4099 | Clopidogrel Besylate | Clopidogrel Besilate | Clopidogrel, (+)(S)-isomer | Plavix | Clopidogrel Bisulfate
Chemical Information
Molecular Formula C16H16ClNO2S
CAS Registry Number 113665-84-2
SMILES COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dry eye06.08.02.001--
Dry mouth07.06.01.0020.000883%
Dry skin23.03.03.001--
Duodenal ulcer07.04.02.0020.000932%
Duodenal ulcer haemorrhage24.07.02.020; 07.04.02.0040.000589%Not Available
Duodenal ulcer perforation07.04.02.0030.000147%Not Available
Duodenitis haemorrhagic24.07.02.025; 07.08.03.0100.000147%Not Available
Dysaesthesia17.02.06.0030.000245%
Dysarthria19.19.03.001; 17.02.08.0010.001815%
Dysgeusia17.02.07.003; 07.14.03.001--
Dyskinesia17.01.02.0060.000442%
Dyspepsia07.01.02.0010.001619%
Dysphagia07.01.06.0030.001864%
Dysphonia19.19.03.002; 17.02.08.004; 22.02.05.005--
Dyspnoea22.02.01.004; 02.01.03.0020.008046%
Dyspnoea at rest22.02.01.025; 02.01.03.0070.000196%Not Available
Dyspnoea exertional22.02.01.005; 02.01.03.003--Not Available
Dysuria20.02.02.0020.000540%
Ear disorder04.03.01.001--Not Available
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.0010.001226%Not Available
Eczema23.03.04.0060.000442%
Electrocardiogram abnormal13.14.05.001--Not Available
Electrocardiogram QT prolonged13.14.05.004--
Electrocardiogram ST segment depression13.14.05.0050.000147%Not Available
Electrocardiogram ST segment elevation13.14.05.0250.000343%Not Available
Electroencephalogram abnormal13.07.03.0010.000098%Not Available
Embolic stroke24.01.04.010; 17.08.01.0320.000128%Not Available
Embolism venous24.01.01.0030.000026%Not Available
Encephalopathy17.13.02.001--
Enterocolitis07.08.03.0030.000098%
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