ADReCS

Pharmaceutical Information

Drug Name	Clopidogrel
Drug ID	BADD_D00504
Description	Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213] It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin.[A180547] Clopidogrel was granted FDA approval on 17 November 1997.[L7213]
Indications and Usage	Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213]
Marketing Status	approved
ATC Code	B01AC04
DrugBank ID	DB00758
KEGG ID	D07729; D10823; D10824
MeSH ID	D000077144
PubChem ID	60606
TTD Drug ID	D0N0TZ
NDC Product Code	42543-714; 50090-4918; 52605-083; 16729-218; 0024-1171; 68788-8190; 72578-012; 65977-0037; 52605-082; 63187-362; 63629-4728; 70518-0400; 33342-060; 42543-713; 65162-414; 0093-7314; 16729-219; 61919-007; 67296-1840; 50090-2598; 50090-5781; 0024-1332; 61919-737; 70771-1062; 16714-052; 68071-2813; 68071-4138; 71335-0581
UNII	A74586SNO7
Synonyms	Clopidogrel \| SC 25989C \| SC 25990C \| SR 25989 \| Clopidogrel-Mepha \| Clopidogrel Mepha \| Clopidogrel Sandoz \| Iscover \| Clopidogrel Napadisilate \| Clopidogrel Hydrochloride \| PCR 4099 \| PCR-4099 \| Clopidogrel Besylate \| Clopidogrel Besilate \| Clopidogrel, (+)(S)-isomer \| Plavix \| Clopidogrel Bisulfate

Chemical Information

Molecular Formula	C16H16ClNO2S
CAS Registry Number	113665-84-2
SMILES	COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Mediastinal haemorrhage	24.07.01.075; 22.09.03.008	0.000032%
Cell death	14.11.02.005; 08.03.03.003	0.000021%		Not Available
Peripheral artery occlusion	24.04.03.022	0.000021%		Not Available
Subacute cutaneous lupus erythematosus	10.04.03.012; 23.03.02.020; 15.06.02.012	0.000021%		Not Available
Sopor	19.02.04.002; 17.02.04.021	0.000139%		Not Available
Haemorrhagic cyst	24.07.01.069; 16.02.02.013; 08.03.05.008	0.000021%		Not Available
Intracranial haematoma	24.07.04.027; 17.08.01.051	0.000021%		Not Available
Coronary artery perforation	12.02.01.022; 02.02.01.014	0.000053%		Not Available
Haemorrhagic ascites	24.07.02.032; 09.01.05.007; 07.07.02.003	0.000064%		Not Available
Gastrointestinal erosion	07.04.04.009	0.000053%		Not Available
Embolic cerebral infarction	24.01.04.009; 17.08.01.029	0.000021%		Not Available
Diffuse alveolar damage	22.01.01.019	0.000032%		Not Available
Arterial haemorrhage	24.07.01.063	0.000075%		Not Available
Cerebellar haematoma	24.07.04.022; 17.08.01.045	0.000021%		Not Available
Communication disorder	19.19.01.008	0.000021%		Not Available
Deformity	08.01.03.022	0.000107%		Not Available
Small intestinal stenosis	07.13.06.008	0.000021%
Bladder tamponade	24.07.01.064; 20.02.02.024	0.000021%		Not Available
Basilar artery thrombosis	24.01.04.014; 17.08.01.043	0.000053%		Not Available
Renal embolism	20.01.07.014; 24.01.11.003	0.000021%		Not Available
Breast haematoma	24.07.03.020; 21.05.05.013	0.000021%		Not Available
Eyelid haematoma	23.06.07.007; 12.01.04.025; 06.07.05.002; 24.07.05.013	0.000032%		Not Available
Gastric fistula	12.02.03.018; 07.11.05.011	0.000021%
Basal ganglia haemorrhage	17.08.01.039; 24.07.04.021	0.000053%		Not Available
Carotid arteriosclerosis	17.08.02.015; 24.04.06.031	0.000021%		Not Available
Cerebral microhaemorrhage	24.07.04.025; 17.08.02.019	0.000032%		Not Available
Abdominal wall haematoma	24.07.02.039; 07.16.05.005	0.000160%		Not Available
Apparent death	08.01.03.062	0.000021%		Not Available
Dieulafoy's vascular malformation	24.03.03.025; 07.15.04.002	0.000032%		Not Available
Respiratory fatigue	22.02.01.042	0.000021%		Not Available

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