ADReCS

Pharmaceutical Information

Drug Name	Clopidogrel
Drug ID	BADD_D00504
Description	Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213] It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin.[A180547] Clopidogrel was granted FDA approval on 17 November 1997.[L7213]
Indications and Usage	Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213]
Marketing Status	approved
ATC Code	B01AC04
DrugBank ID	DB00758
KEGG ID	D07729; D10823; D10824
MeSH ID	D000077144
PubChem ID	60606
TTD Drug ID	D0N0TZ
NDC Product Code	42543-714; 50090-4918; 52605-083; 16729-218; 0024-1171; 68788-8190; 72578-012; 65977-0037; 52605-082; 63187-362; 63629-4728; 70518-0400; 33342-060; 42543-713; 65162-414; 0093-7314; 16729-219; 61919-007; 67296-1840; 50090-2598; 50090-5781; 0024-1332; 61919-737; 70771-1062; 16714-052; 68071-2813; 68071-4138; 71335-0581
UNII	A74586SNO7
Synonyms	Clopidogrel \| SC 25989C \| SC 25990C \| SR 25989 \| Clopidogrel-Mepha \| Clopidogrel Mepha \| Clopidogrel Sandoz \| Iscover \| Clopidogrel Napadisilate \| Clopidogrel Hydrochloride \| PCR 4099 \| PCR-4099 \| Clopidogrel Besylate \| Clopidogrel Besilate \| Clopidogrel, (+)(S)-isomer \| Plavix \| Clopidogrel Bisulfate

Chemical Information

Molecular Formula	C16H16ClNO2S
CAS Registry Number	113665-84-2
SMILES	COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Oropharyngeal discomfort	22.12.03.015; 07.05.05.008	0.000032%		Not Available
Neurological decompensation	17.02.05.030	0.000032%		Not Available
Kounis syndrome	24.04.04.020; 10.01.03.037; 02.02.02.020	0.000043%		Not Available
Acute kidney injury	20.01.03.016	0.000578%
Upper-airway cough syndrome	22.12.03.036	0.000047%
Hypoxic-ischaemic encephalopathy	22.02.02.011; 17.13.02.006; 24.04.06.021	0.000021%		Not Available
Foetal growth restriction	18.03.01.002	0.000053%
Slow speech	19.19.02.004; 17.02.08.016	0.000021%		Not Available
Drug-induced liver injury	12.03.01.044; 09.01.07.023	0.000235%		Not Available
Peripheral artery stenosis	24.04.03.017	0.000032%		Not Available
Peripheral artery thrombosis	24.01.02.010	0.000021%		Not Available
Drug reaction with eosinophilia and systemic symptoms	23.03.05.005; 10.01.01.021; 12.03.01.064	0.000235%		Not Available
Language disorder	19.19.01.006; 17.02.08.015	0.000043%		Not Available
Mouth swelling	23.04.01.020; 10.01.05.020; 07.05.04.007	0.000043%		Not Available
Multiple organ dysfunction syndrome	08.01.03.057	0.000267%
Device related thrombosis	24.01.01.027; 08.07.05.001	-	-	Not Available
Abdominal mass	07.01.01.003	0.000043%		Not Available
Alcohol interaction	08.06.03.003	0.000021%		Not Available
Alopecia areata	23.02.02.008; 10.04.02.011	0.000043%		Not Available
Arterial rupture	24.03.02.027; 12.01.11.010	0.000075%		Not Available
Blood blister	23.03.01.028; 12.01.06.013	0.000021%		Not Available
Cardiac aneurysm	24.02.02.004; 02.04.02.030	0.000021%		Not Available
Cardiac failure chronic	02.05.01.009	0.000064%		Not Available
Cerebellar haemorrhage	24.07.04.023; 17.08.01.046	0.000107%		Not Available
Cerebral artery thrombosis	24.01.04.008; 17.08.01.026	0.000021%		Not Available
Cervical cord compression	17.10.02.002	0.000043%		Not Available
Chronic gastritis	11.07.01.016; 10.04.04.011; 07.08.02.005	0.000032%		Not Available
Colonic haematoma	07.12.03.006; 24.07.02.042	0.000021%		Not Available
Dermatitis exfoliative generalised	23.03.07.002; 10.01.01.029	0.000043%		Not Available
Diverticulum intestinal haemorrhagic	24.07.02.043; 07.10.01.003	0.000107%		Not Available

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