Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clomiphene citrate
Drug ID BADD_D00498
Description A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
Indications and Usage Used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome) to induce ovulation.
Marketing Status Prescription; Discontinued
ATC Code G03GB02
DrugBank ID DB00882
KEGG ID D00962
MeSH ID D002996
PubChem ID 60974
TTD Drug ID D0I5WB
NDC Product Code 63275-9964; 49884-701; 73309-046; 17369-817; 50090-0678; 63629-2165; 63629-5302; 68071-4676; 38779-0390; 62991-3139; 51927-0183; 73309-017; 43647-456; 61919-375; 10577-916; 51927-0056; 46014-1122; 62991-2702; 51552-1580; 48087-0025; 71052-338; 49169-1040; 68071-2638; 73309-047; 68981-028; 48087-0144
Synonyms Clomiphene | Clomifene | Chloramiphene | Clomifen | Clomiphene Citrate | Citrate, Clomiphene | Clomiphene Hydrochloride | Hydrochloride, Clomiphene | Serophene | Gravosan | Klostilbegit | Clostilbegit | Clomid | Clomide | Dyneric
Chemical Information
Molecular Formula C32H36ClNO8
CAS Registry Number 50-41-9
SMILES CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O) O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vitreous detachment12.01.04.005; 06.09.01.002--Not Available
Vitreous floaters06.09.01.005--
Vomiting07.01.07.003--
Vulvovaginal dryness21.08.02.003--
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Breast discomfort21.05.05.007--Not Available
Transaminases increased13.03.01.015--Not Available
Neuroectodermal neoplasm17.20.01.006; 16.30.01.006--Not Available
Ear, nose and throat examination abnormal13.15.01.020--Not Available
Benign anorectal neoplasm16.05.02.002; 07.20.01.004--Not Available
Psychotic disorder19.03.01.002--
Hepatoblastoma16.07.04.001; 09.04.02.003--Not Available
Retinal vascular thrombosis24.01.07.001; 06.10.01.004--Not Available
Congenital foot malformation15.11.07.002; 03.11.07.002--Not Available
Congenital hand malformation15.11.07.005; 03.11.07.005--Not Available
Congenital jaw malformation15.11.05.003; 03.11.05.003--Not Available
Congenital joint malformation15.11.06.004; 03.11.06.004--Not Available
Congenital musculoskeletal anomaly15.11.06.002; 03.11.06.002--Not Available
Skull malformation15.11.02.003; 03.11.02.003--Not Available
Renal aplasia20.01.02.001; 03.06.01.002--Not Available
Chronic kidney disease20.01.03.017--
Ovarian haemorrhage24.07.03.009; 21.11.02.006--
Dysmorphism15.11.06.001; 03.11.06.001--Not Available
Hepatic angiosarcoma24.03.06.007; 09.04.02.007; 16.07.02.003--Not Available
Cloacal exstrophy07.11.04.005; 03.03.02.004; 21.15.02.003; 20.08.03.004--Not Available
Renal cell carcinoma20.01.04.003; 16.08.02.002--Not Available
Intellectual disability19.21.06.001; 17.03.07.001--Not Available
Hepatocellular carcinoma16.07.02.005; 09.04.02.010--Not Available
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