Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clomiphene citrate
Drug ID BADD_D00498
Description A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
Indications and Usage Used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome) to induce ovulation.
Marketing Status Prescription; Discontinued
ATC Code G03GB02
DrugBank ID DB00882
KEGG ID D00962
MeSH ID D002996
PubChem ID 60974
TTD Drug ID D0I5WB
NDC Product Code 63275-9964; 49884-701; 73309-046; 17369-817; 50090-0678; 63629-2165; 63629-5302; 68071-4676; 38779-0390; 62991-3139; 51927-0183; 73309-017; 43647-456; 61919-375; 10577-916; 51927-0056; 46014-1122; 62991-2702; 51552-1580; 48087-0025; 71052-338; 49169-1040; 68071-2638; 73309-047; 68981-028; 48087-0144
Synonyms Clomiphene | Clomifene | Chloramiphene | Clomifen | Clomiphene Citrate | Citrate, Clomiphene | Clomiphene Hydrochloride | Hydrochloride, Clomiphene | Serophene | Gravosan | Klostilbegit | Clostilbegit | Clomid | Clomide | Dyneric
Chemical Information
Molecular Formula C32H36ClNO8
CAS Registry Number 50-41-9
SMILES CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O) O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pituitary tumour16.24.01.003; 05.03.05.002--Not Available
Plasma cell myeloma01.14.02.004; 16.23.02.004--Not Available
Pollakiuria20.02.02.007--
Prolactinoma17.18.01.003; 16.09.01.003; 05.03.05.001--Not Available
Pruritus23.03.12.001--
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Retinal haemorrhage24.07.05.003; 06.10.01.001--Not Available
Retinal vascular disorder24.03.07.002; 06.10.01.002--
Seizure17.12.03.001--
Spine malformation15.11.04.001; 03.11.04.001--Not Available
Syncope02.01.02.008; 24.06.02.012; 17.02.04.008--
Tachycardia02.03.02.007--Not Available
Tension19.06.02.005--Not Available
Thrombophlebitis24.01.02.001--Not Available
Thyroid disorder05.02.01.002--Not Available
Thyroid neoplasm16.24.01.002; 05.02.05.002--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tongue neoplasm malignant stage unspecified16.13.07.003; 07.21.07.003--Not Available
Tracheo-oesophageal fistula22.04.07.003; 03.16.02.002; 07.11.05.003--Not Available
Trisomy 2103.12.01.003; 02.08.02.003; 19.21.06.005; 17.03.07.005--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Uterine haemorrhage24.07.03.004; 21.07.01.005--
Vasoconstriction24.04.03.008; 23.06.05.007--Not Available
Ventricular septal defect03.07.02.001; 02.04.02.007--Not Available
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.007--
Visual acuity tests abnormal13.07.04.009--Not Available
Visual field defect06.02.07.003; 17.17.01.001--Not Available
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