| Drug Name |
Clodronic acid |
| Drug ID |
BADD_D00494 |
| Description |
Clodronic acid is a first generation bisphosphonate similar to [etidronic acid] and [tiludronic acid].[A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification.[A1923] clodronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate [zoledronic acid], [ibandronic acid], [minodronic acid], and [risedronic acid].[A203111]
Clodronic acid is not FDA approved, but is approved in Canada.[L13910] |
| Indications and Usage |
Clodronic acid is indicated as an adjunct in the management of osteolysis from bone metastases of malignant tumors and for management of hypercalcemia of malignancy.[L13910] |
| Marketing Status |
approved; investigational; vet_approved |
| ATC Code |
M05BA02 |
| DrugBank ID |
DB00720
|
| KEGG ID |
D03545
|
| MeSH ID |
D004002
|
| PubChem ID |
25419
|
| TTD Drug ID |
D00HNB
|
| NDC Product Code |
Not Available |
| UNII |
0813BZ6866
|
| Synonyms |
Clodronic Acid | Acid, Clodronic | Dichloromethane Diphosphonate | Diphosphonate, Dichloromethane | Dichloromethylenebisphosphonate | Dichloromethanediphosphonic Acid | Acid, Dichloromethanediphosphonic | Dichloromethylene Biphosphonate | Biphosphonate, Dichloromethylene | Dichloromethylene Diphosphonate | Diphosphonate, Dichloromethylene | Cl2MDP | Dichloromethanediphosphonate | Clodronate | Clodronate Disodium | Disodium, Clodronate | Clodronate Sodium | Sodium, Clodronate | Bonefos |
