Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clobetasol propionate
Drug ID BADD_D00490
Description Clobetasol propionate is a prednisolone derivative with higher specificity for glucocorticoid receptors than mineralocorticoid receptors.[L11815] It has demonstrated superior activity compared to [fluocinonide][A190963] and was first described in the literature in 1974.[A190936] Clobetasol Propionate was granted FDA approval on 27 December 1985.[L11809]
Indications and Usage For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
Marketing Status Prescription; Discontinued
ATC Code D07AD01
DrugBank ID DB01013
KEGG ID D01272
MeSH ID D002990
PubChem ID 32798
TTD Drug ID D0H0YD
NDC Product Code 63629-8637; 63739-064; 43538-950; 71589-004; 0168-0301; 50742-304; 43538-951; 50383-269; 63629-8639; 50383-267; 68071-1599; 0378-8055; 71589-002; 63629-2395; 50383-978; 49452-2141; 51672-1258; 71589-003; 63629-2393; 50383-270; 50090-4146; 0781-7137; 70700-106; 70518-2068; 71085-007; 46439-8747; 45802-637; 45802-961; 72189-262; 0299-3848; 0378-8147; 62559-980; 40032-028; 0472-0400; 16714-992; 70752-153; 62332-547; 68071-4706; 76003-0325; 71589-007; 51672-1347; 52565-051; 0168-0163; 50090-2289; 43386-096; 51672-4193; 0299-3847; 0378-8167; 33342-321; 52128-158; 70710-1401; 51672-1371; 63629-2330; 0299-3849; 0472-0404; 68462-625; 59088-762; 68788-7768; 52565-082; 70700-109; 70771-1498; 68788-7212; 68040-713; 10337-163; 69238-1732; 42291-076; 63629-2332; 0168-0269; 40032-096; 0472-0403; 63629-2392; 68462-532; 51672-1293; 71428-005; 62991-1492; 63629-2331; 71205-151; 50090-5778; 51672-1297; 70771-1209; 66993-939; 51672-1350; 52565-094; 68180-956; 68462-530; 64958-0101; 62332-425; 0168-0293; 69238-1532; 45802-437; 68462-608; 22552-0006; 79572-008; 16714-730; 62332-486; 13668-603; 50383-266; 70518-1178; 50090-5264; 70771-1080; 0713-0656; 51927-2627; 60429-901; 45802-925; 50090-5488; 51672-1294; 49502-537; 60432-133; 62332-465; 0168-0162; 50090-4630; 70710-1456; 50090-3820; 72578-085; 13668-569; 43538-953; 16714-030; 43538-952; 68462-529; 51552-0605; 68180-536; 63629-2329; 10337-162; 42571-362; 69482-700; 50383-268; 42291-077; 0378-8182; 64980-441; 50090-4647; 50090-5079; 68462-480; 52565-055; 50090-2405; 68180-551; 0472-0402; 51672-1259; 0591-4039; 63646-500; 63629-8638; 16714-782; 50383-979; 63629-2394; 52565-039; 60429-902; 46439-8708; 68382-998; 43386-028; 68071-1600; 68788-7581; 62332-548; 70771-1442; 71589-006; 50090-0548
Synonyms Clobetasol | Clofenazon | Clobetasol Propionate | Clobetasol 17-Propionate | Clobetasol 17 Propionate | Clobex | Cormax | OLUX | Dermovate | Embeline | Embeline E | Temovate
Chemical Information
Molecular Formula C25H32ClFO5
CAS Registry Number 25122-46-7
SMILES CCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CCl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Adrenal insufficiency05.01.02.001; 14.11.01.0040.000930%
Adrenal suppression14.11.01.005; 05.01.02.0020.000797%Not Available
Alopecia23.02.02.0010.000266%
Application site atrophy12.07.01.037; 08.02.01.037--Not Available
Application site irritation12.07.01.003; 08.02.01.003--Not Available
Application site pain12.07.01.004; 08.02.01.004--Not Available
Application site pruritus23.03.12.004; 12.07.01.005; 08.02.01.005--Not Available
Application site reaction12.07.01.006; 08.02.01.006--Not Available
Arthralgia15.01.02.0010.000266%
Atrophy08.03.04.001--Not Available
Back pain15.03.04.0050.000399%
Blood cholesterol increased13.12.01.0020.000266%
Blood cortisol decreased13.10.09.0040.000532%Not Available
Blood triglycerides increased13.12.03.0010.000266%Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Cerebral atrophy17.11.01.0010.000532%Not Available
Crepitations08.01.03.006--Not Available
Cushing's syndrome24.08.04.001; 19.07.03.002; 14.11.01.007; 05.01.01.0010.002658%Not Available
Cushingoid05.01.01.002; 24.08.02.004; 19.07.03.001; 14.11.01.0060.000532%
Delusion19.10.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis acneiform23.02.01.004--
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Dermatitis infected23.03.04.024; 11.01.12.011--Not Available
Discomfort08.01.08.0030.000266%Not Available
Drug eruption23.03.05.001; 08.01.06.015; 10.01.01.0050.000266%Not Available
Dry skin23.03.03.001--
Erythema23.03.06.0010.000797%Not Available
Eye irritation06.04.05.003--Not Available
Folliculitis11.01.12.018; 23.09.04.007--
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