| Drug Name |
Clindamycin |
| Drug ID |
BADD_D00483 |
| Description |
Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms[L11599,L11596] as well as topically for acne vulgaris.[L11593] It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and bacilli and gram-negative bacilli.[A190621] Interestingly, clindamycin appears to carry some activity against protozoans, and has been used off-label in the treatment of toxoplasmosis, malaria, and babesiosis.[A190657]
Clindamycin is derived from, and has largely replaced, [lincomycin], a naturally occurring lincosamide and the eponymous member of this antibiotic class, due to its improved properties over the parent compound. The name lincomycin is derived from Lincoln, Nebraska, where it was first isolated from _Streptomyces lincolnensis_ found in a soil sample.[A190621] |
| Indications and Usage |
For the treatment of serious infections caused by susceptible anaerobic bacteria, including Bacteroides spp., Peptostreptococcus, anaerobic streptococci, Clostridium spp., and microaerophilic streptococci. May be useful in polymicrobic infections such as intra-abdominal or pelvic infections, osteomyelitis, diabetic foot ulcers, aspiration pneumonia and dental infections. May also be used to treat MSSA and respiratory infections caused by S. pneumoniae and S. pyogenes in patients who are intolerant to other indicated antibiotics or who are infected with resistant organism. May be used vaginally to treat vaginosis caused by Gardnerella vaginosa. Clindamycin reduces the toxin producing effects of S. aureus and S. pyogenes and as such, may be particularly useful for treating necrotizing fasciitis. May be used topically to treat acne. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
D10AF01; G01AA10; J01FF01 |
| DrugBank ID |
DB01190
|
| KEGG ID |
D00277
|
| MeSH ID |
D002981
|
| PubChem ID |
2786
|
| TTD Drug ID |
D0R0ZL
|
| NDC Product Code |
67457-814; 71872-7168; 67457-817; 16781-462 |
| Synonyms |
Clindamycin | Chlolincocin | 7-Chloro-7-deoxylincomycin | 7 Chloro 7 deoxylincomycin | Chlorlincocin | Dalacin C | Clindamycin Monohydrochloride | Monohydrochloride, Clindamycin | Clindamycin Monohydrochloride, Monohydrate | Monohydrate Clindamycin Monohydrochloride | Monohydrochloride, Monohydrate Clindamycin | Cleocin | Clindamycin Hydrochloride | Hydrochloride, Clindamycin |
