Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cidofovir
Drug ID BADD_D00463
Description Cidofovir is an injectable antiviral medication employed in the treatment of cytomegalovirus (CMV) retinitis in patients diagnosed with AIDS. It suppresses CMV replication through selective inhibition of viral DNA synthesis.[FDA label] It was manufactured by _Gilead_ and initially approved by the FDA in 1996, but has since been discontinued.[L6223]
Indications and Usage For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)
Marketing Status Prescription; Discontinued
ATC Code J05AB12
DrugBank ID DB00369
KEGG ID C06909
MeSH ID D000077404
PubChem ID 60613
TTD Drug ID D04AAW
NDC Product Code 48954-728
Synonyms Cidofovir | HPMPC | GS 504 | GS-504 | GS504 | Cidofovir, Sodium Salt | Cidofovir Sodium | Cidofovir, (R)-isomer | Cidofovir Anhydrous | 1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine | 1-((3-Hydroxy-2-phosphonylmethoxy)propyl)cytosine | Vistide | Cidofovir, (+-)-isomer
Chemical Information
Molecular Formula C8H14N3O6P
CAS Registry Number 113852-37-2
SMILES C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ApoptosisPre-mRNA-processing factor 19Q9UMS4Not Available11697818; 10338155; 11948417
ApoptosisCellular tumor antigen p53P04637T1573911697818; 10338155; 11948417
ApoptosisPutative cyclin-dependent kinase inhibitor 1A (P21/WAF1/CIP1)Q683K8Not Available11697818; 10338155; 11948417
ApoptosisCaspase-3P42574T5794311697818; 10338155; 11948417
Nephropathy toxicSolute carrier family 22 member 6Q4U2R8Not Available10462545; 10703662; 10991954
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Proctitis07.08.04.001--
Prostatic disorder21.04.01.001--Not Available
Proteinuria20.02.01.011--
Pruritus23.03.12.001--
Pseudolymphoma01.09.01.016--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Refraction disorder06.02.04.004--Not Available
Renal failure20.01.03.005--Not Available
Renal tubular disorder20.05.03.004--Not Available
Respiratory alkalosis22.02.02.005; 14.01.05.001--Not Available
Retinal detachment12.01.04.004; 06.09.03.003--
Retinal disorder06.08.03.005--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Sarcoma16.33.01.002; 15.09.03.002--Not Available
Seborrhoea23.02.07.001--Not Available
Seborrhoeic dermatitis23.03.04.018--Not Available
Seizure17.12.03.001--
Sepsis11.01.11.003--
Shock24.06.02.002--Not Available
Sinusitis22.07.03.007; 11.01.13.005--
Skin discolouration23.03.03.005--Not Available
Skin disorder23.03.03.007--Not Available
Skin hypertrophy23.01.04.002--Not Available
Skin ulcer24.04.03.007; 23.07.03.003--
Somnolence17.02.04.006; 19.02.05.003--
Speech disorder22.02.05.034; 19.19.02.002; 17.02.08.003--Not Available
Spleen disorder01.09.02.003--Not Available
Splenomegaly01.09.02.001--Not Available
Sputum increased22.02.03.007--Not Available
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