Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cholestyramine
Drug ID BADD_D00451
Description Cholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins. Cholestyramine resin is quite hydrophilic, but insoluble in water.
Indications and Usage Indicated as adjunctive therapy to diet for the reduction of elevated serum cholesterol in patients with primary hypercholesterolemia (elevated low density lipoprotein [LDL] cholesterol) who do not respond adequately to diet. Also for the relief of pruritus associated with partial biliary obstruction.
Marketing Status Prescription; Discontinued
ATC Code C10AC01
DrugBank ID DB01432
KEGG ID D02690
MeSH ID D002792
PubChem ID 137699107
TTD Drug ID Not Available
NDC Product Code 63629-2163; 46144-315; 0245-0536; 0185-0940; 42806-267; 68382-528; 42806-265; 49884-936; 0832-0536; 63629-2161; 50090-3415; 0245-0036; 49884-466; 62559-620; 71052-151; 53933-2175; 51224-009; 68444-0001; 70771-1105; 70771-1070; 68382-529; 63629-2162; 27241-134; 51927-4962; 42806-266; 51224-011; 63629-2164; 49884-465; 49884-937
Synonyms Cholestyramine Resin | Cholestyramine Resins | Resin, Cholestyramine | Resins, Cholestyramine | Colestyramin | Colestyramins | Colestyramine | Colestyramines | Cholestyramine | Cholestyramines | MK-135 | MK 135 | MK135 | Questran | Questrans | Cuemid | Cuemids | Quantalan | Quantalans
Chemical Information
Molecular Formula C27H47ClN2
CAS Registry Number 11041-12-6
SMILES CCC(C)C.CCC(CC(C)C1=CC=CC=C1)C2=CC=C(C=C2)C[N+](C)(C)C.N.[Cl-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.0020.002480%
Abdominal pain lower07.01.05.0100.001654%Not Available
Abdominal pain upper07.01.05.0030.002480%
Acidosis hyperchloraemic14.01.01.007--Not Available
Anaemia01.03.02.001--
Anal fistula07.11.05.0020.001654%
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Asthma10.01.03.010; 22.03.01.002--Not Available
Back pain15.03.04.005--
Biliary colic09.02.01.001--Not Available
Calcification metastatic14.04.01.011; 08.03.04.006--Not Available
Choking22.02.05.0010.005787%Not Available
Colitis07.08.01.0010.001654%
Colitis ulcerative10.02.01.004; 07.08.01.0050.001654%Not Available
Constipation07.02.02.001--
Cough22.02.03.0010.002480%
Crohn's disease10.02.01.005; 07.08.01.0150.002480%Not Available
Death08.04.01.001--
Delirium19.13.02.0010.001654%
Dental caries07.09.01.001--
Diarrhoea07.02.01.0010.006614%
Diverticulitis11.01.07.003; 07.10.02.001--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Duodenal ulcer haemorrhage24.07.02.020; 07.04.02.004--Not Available
Dysgeusia17.02.07.003; 07.14.03.001--
Dysphagia07.01.06.0030.003307%
Dyspnoea22.02.01.004; 02.01.03.002--
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