Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Chlorpromazine
Drug ID BADD_D00445
Description The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
Indications and Usage For the treatment of schizophrenia; to control nausea and vomiting; for relief of restlessness and apprehension before surgery; for acute intermittent porphyria; as an adjunct in the treatment of tetanus; to control the manifestations of the manic type of manic-depressive illness; for relief of intractable hiccups; for the treatment of severe behavioral problems in children (1 to 12 years of age) marked by combativeness and/or explosive hyperexcitable behavior (out of proportion to immediate provocations), and in the short-term treatment of hyperactive children who show excessive motor activity with accompanying conduct disorders consisting of some or all of the following symptoms: impulsivity, difficulty sustaining attention, aggressivity, mood lability, and poor frustration tolerance.
Marketing Status approved; investigational; vet_approved
ATC Code N05AA01
DrugBank ID DB00477
KEGG ID D00270
MeSH ID D002746
PubChem ID 2726
TTD Drug ID D01ZII
NDC Product Code 62332-735; 70518-3175; 63304-083; 63304-114; 62332-738; 62332-737; 63304-122; 62332-739; 63304-143; 62332-736; 63304-185
UNII U42B7VYA4P
Synonyms Chlorpromazine | Thorazine | Aminazine | Largactil | Chlordelazine | Chlorpromazine Hydrochloride | Hydrochloride, Chlorpromazine | Contomin | Fenactil | Propaphenin | Chlorazine
Chemical Information
Molecular Formula C17H19ClN2S
CAS Registry Number 34468-21-8
SMILES CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.0120.002506%
Agranulocytosis01.02.03.0010.000677%Not Available
Akathisia19.06.02.006; 17.01.02.0020.000677%
Altered state of consciousness19.07.01.003; 17.02.04.0010.000677%Not Available
Amenorrhoea21.01.02.001; 05.05.01.002--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Apathy19.04.04.002--Not Available
Aphasia19.21.01.001; 17.02.03.001--
Aplastic anaemia01.03.03.002--Not Available
Apnoea22.02.01.001--
Asphyxia22.02.02.001; 12.01.08.011--Not Available
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Body temperature increased13.15.01.001--Not Available
Breast engorgement21.05.05.002; 18.08.02.001--Not Available
Cardiac arrest02.03.04.001--
Cardio-respiratory arrest02.03.04.002; 22.02.06.0070.001355%Not Available
Catatonia19.11.01.0010.000677%Not Available
Choking22.12.03.003--Not Available
Cholestasis09.01.01.001--Not Available
Circulatory collapse24.06.02.001--Not Available
Cogwheel rigidity17.01.05.001; 15.05.04.006--Not Available
Coma17.02.09.0010.001016%Not Available
Completed suicide08.04.01.010; 19.12.01.0010.001693%Not Available
Condition aggravated08.01.03.0040.000677%Not Available
Conduction disorder02.03.01.0080.000677%
Confusional state19.13.01.001; 17.02.03.0050.001355%
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ADReCS-Target
Drug Name ADR Term Target
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