Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Chlorambucil
Drug ID BADD_D00429
Description A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Indications and Usage For treatment of chronic lymphatic (lymphocytic) leukemia, childhood minimal-change nephrotic syndrome, and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, Hodgkin's disease, non-Hodgkin's lymphomas, and Waldenström’s Macroglobulinemia.
Marketing Status Prescription
ATC Code L01AA02
DrugBank ID DB00291
KEGG ID D00266
MeSH ID D002699
PubChem ID 2708
TTD Drug ID D0V8QT
NDC Product Code 71052-212; 76055-0025; 76388-635; 72969-010; 50683-0384; 49452-1911; 43744-066
Synonyms Chlorambucil | 4-(Bis(2-chloroethyl)amino)benzenebutanoic Acid | N,N-Di-(2-chloroethyl)-p-aminophenylbutyric Acid | Chloraminophene | Chlorbutin | NSC-3088 | NSC 3088 | NSC3088 | Leukeran | Lympholysin | Amboclorin | CB-1348 | CB 1348 | CB1348
Chemical Information
Molecular Formula C14H19Cl2NO2
CAS Registry Number 305-03-3
SMILES C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Herpes zoster23.09.03.002; 11.05.02.0030.000533%
Hyperhidrosis23.02.03.004; 08.01.03.0280.001066%
Hyperpyrexia08.05.02.0020.000533%Not Available
Hypersensitivity10.01.03.0030.000799%
Hyperuricaemia14.09.01.003--
Hyponatraemia14.05.04.0020.000799%
Hypotension24.06.03.0020.002931%
Hypoxia22.02.02.0030.000799%
Infection11.01.08.002--Not Available
Infertility21.03.02.001--Not Available
Interstitial lung disease22.01.02.003; 10.02.01.033--Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Leukaemia16.01.03.001; 01.10.03.001--
Leukopenia01.02.02.0010.001865%Not Available
Lymphadenopathy01.09.01.0020.000533%Not Available
Lymphocyte count decreased13.01.06.0060.000533%
Lymphopenia01.02.02.0020.000799%Not Available
Malaise08.01.01.0030.001865%
Mouth ulceration07.05.06.004--Not Available
Movement disorder17.01.02.010--Not Available
Mucosal inflammation08.01.06.002--Not Available
Muscle twitching15.05.03.005--Not Available
Myelodysplastic syndrome01.10.04.001; 16.01.04.001--
Myocardial infarction24.04.04.009; 02.02.02.0070.000417%
Myoclonus17.02.05.008--Not Available
Nausea07.01.07.001--
Neoplasm16.16.02.001--Not Available
Neoplasm malignant16.16.01.001--Not Available
Nephrotic syndrome20.05.01.002--
Neuritis17.09.03.001--Not Available
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