Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cerivastatin
Drug ID BADD_D00415
Description On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal Rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Canadian market.
Indications and Usage Used as an adjunct to diet for the reduction of elevated total and LDL cholesterol levels in patients with primary hypercholesterolemia and mixed dyslipidemia (Fredrickson Types IIa and IIb) when the response to dietary restriction of saturated fat and cholesterol and other non-pharmacological measures alone has been inadequate.
Marketing Status Discontinued
ATC Code C10AA06
DrugBank ID DB00439
KEGG ID D07661
MeSH ID C086276
PubChem ID 446156
TTD Drug ID D03KIA
NDC Product Code Not Available
Synonyms cerivastatin | Kazak | cerivastatin sodium | 6-Heptenoic acid, 7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-, monosodium salt, (S-(R*,S*-(E)))- | 7-(4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyrid-3-yl)-3,5-dihydroxy-6-heptenoate sodium salt | rivastatin | Certa | Bay w 6228 | Baycol | Lipobay
Chemical Information
Molecular Formula C26H34FNO5
CAS Registry Number 145599-86-6
SMILES CC(C)C1=C(C(=C(C(=N1)C(C)C)COC)C2=CC=C(C=C2)F)C=CC(CC(CC(=O)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Muscular weakness17.05.03.005; 15.05.06.001--
Myalgia15.05.02.001--
Myoglobinuria20.02.01.010; 15.05.03.009; 02.04.02.006--Not Available
Myoglobin urine present13.16.02.002--Not Available
Myopathy15.05.05.001--Not Available
Myositis15.05.01.001--
Nausea07.01.07.001--
Neuropathy peripheral17.09.03.003--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Ophthalmoplegia17.17.02.005; 06.05.02.003--Not Available
Pain in extremity15.03.04.010--
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005--
Paralysis17.01.04.004--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photosensitivity reaction23.03.09.003--
Polymyalgia rheumatica15.06.01.001; 10.04.05.003--Not Available
Pruritus23.03.12.001--
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Rash23.03.13.001--Not Available
Rhabdomyolysis15.05.05.002--
Rhinitis22.07.03.006; 11.01.13.004--
Sinusitis11.01.13.005; 22.07.03.007--
Somnolence19.02.05.003; 17.02.04.006--
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Systemic lupus erythematosus10.04.03.004; 23.03.02.006; 15.06.02.003--Not Available
Thrombocytopenia01.08.01.002--Not Available
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006--
Tremor17.01.06.002--
Urticaria23.04.02.001; 10.01.06.001--
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