Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Celiprolol
Drug ID BADD_D00411
Description Celiprolol is indicated for the management of mild to moderate hypertension and effort-induced angina pectoris. It is simultaneously a selective β1 receptor antagonist, a β2 receptor partial agonist and a weak α2 receptor antagonist. In 2010 a clinical trial has suggested a use for this medication in the prevention of vascular complications of a rare inherited disease called vascular Ehlers–Danlos syndrome. This study demonstrated decreased incidence of arterial rupture or dissection (a specific type of arterial rupture in which the layers of the vessel separate prior to complete failure of the artery wall). Celiprolol is not approved for use by the FDA in the treatment of vascular Ehlers–Danlos syndrome.
Indications and Usage Celiprolol is indicated for the management of mild to moderate hypertension and effort-induced angina pectoris.
Marketing Status Not Available
ATC Code C07AB08
DrugBank ID DB04846
KEGG ID D07660
MeSH ID D017272
PubChem ID 2663
TTD Drug ID Not Available
NDC Product Code Not Available
Synonyms Celiprolol | N'-(3-Acetyl-4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)-N,N-diethylurea | Celiprolol, Monohydrochloride, (R)-Isomer | Celiprolol, Monohydrochloride, (S)-Isomer | REV-5320A | REV 5320A | REV5320A | Celiprolol, (R)-Isomer | ST-1396 | ST 1396 | ST1396 | Celiprolol Hydrochloride | Hydrochloride, Celiprolol | Celiprolol Monohydrochloride | Monohydrochloride, Celiprolol | Celiprolol, (+,-)-Isomer | Celiprolol, (S)-Isomer | Selectol
Chemical Information
Molecular Formula C20H33N3O4
CAS Registry Number 56980-93-9
SMILES CCN(CC)C(=O)NC1=CC(=C(C=C1)OCC(CNC(C)(C)C)O)C(=O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Alveolitis allergic22.01.01.002; 10.01.03.008--Not Available
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.001--Not Available
Atrioventricular block02.03.01.002--Not Available
Bradycardia02.03.02.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac failure02.05.01.001--
Confusional state19.13.01.001; 17.02.03.005--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry eye06.08.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Hyperthyroidism05.02.02.001; 14.11.01.011--
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypotension24.06.03.002--
Insomnia19.02.01.002; 17.15.03.002--
Intermittent claudication24.04.03.001--Not Available
Menopausal symptoms21.02.02.002--Not Available
Nausea07.01.07.001--
Nightmare19.02.03.003--Not Available
Palpitations02.01.02.003--
The 1th Page    1 2    Next   Last    Total 2 Pages