Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cefuroxime axetil
Drug ID BADD_D00408
Description Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.
Indications and Usage For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.
Marketing Status Prescription; Discontinued
ATC Code J01DC02; S01AA27
DrugBank ID DB01112
KEGG ID D00914
MeSH ID C040738
PubChem ID 5361467
TTD Drug ID Not Available
NDC Product Code 67877-216; 65862-700; 64679-920; 65862-699; 65862-505; 60429-657; 61788-1000; 16714-400; 65862-339; 50090-0781; 57237-058; 70518-2694; 64679-921; 43063-584; 65862-698; 64679-922; 57237-059; 63187-991; 61919-044; 68180-303; 61919-747; 43063-656; 70934-088; 70518-3215; 43063-623; 50090-4153; 51407-334; 60687-272; 50090-2157; 50090-2159; 72789-035; 16714-401; 68071-1637; 50090-2158; 51407-333; 68180-302; 53002-2670; 43063-657; 68071-4947; 53002-2750; 60429-656; 55289-385; 67877-215
Synonyms cefuroxime axetil | acetoxyethylcefuroxime | cefuroxime 1-acetoxyethyl ester | Ceftin | Zinnat | CCI 15641 | CCI-15641
Chemical Information
Molecular Formula C20H22N4O10S
CAS Registry Number 64544-07-6
SMILES CC(OC(=O)C)OC(=O)C1=C(CSC2N1C(=O)C2NC(=O)C(=NOC)C3=CC=CO3)COC(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Flatulence07.01.04.002--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal infection11.01.07.012; 07.19.02.005--Not Available
Gastrointestinal pain07.01.05.005--
Haemoglobin13.01.05.018--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Hepatitis09.01.07.004--Not Available
Hyperkinesia17.01.02.008--Not Available
Irritability19.04.02.013; 08.01.03.011--
Jarisch-Herxheimer reaction10.02.01.002--Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Joint swelling15.01.02.004--Not Available
Leukopenia01.02.02.001--Not Available
Liver disorder09.01.08.001--Not Available
Mouth ulceration07.05.06.004--Not Available
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Nephropathy toxic20.05.03.002; 12.03.01.010--Not Available
Neutropenia01.02.03.004--Not Available
Pancytopenia01.03.03.003--Not Available
Prothrombin level increased13.01.02.011--Not Available
Prothrombin time prolonged13.01.02.012--Not Available
Pruritus23.03.12.001--
Pseudomembranous colitis11.02.02.002; 07.19.01.003--Not Available
Rash23.03.13.001--Not Available
Renal pain20.02.03.003--Not Available
Salivary hypersecretion07.06.01.009--Not Available
Seizure17.12.03.001--
Serum sickness-like reaction10.01.03.005; 08.01.03.003--Not Available
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