ADReCS

Pharmaceutical Information

Drug Name	Cefuroxime
Drug ID	BADD_D00407
Description	Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.
Indications and Usage	For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.
Marketing Status	approved
ATC Code	J01DC02; S01AA27
DrugBank ID	DB01112
KEGG ID	D00262
MeSH ID	D002444
PubChem ID	41375
TTD Drug ID	D0Y2IE
NDC Product Code	0143-9567; 0143-9569; 0143-9976; 0143-9568; 0143-9977; 0143-9979
UNII	O1R9FJ93ED
Synonyms	Cefuroxime \| Cephuroxime \| Zinacef \| Ketocef

Chemical Information

Molecular Formula	C16H16N4O8S
CAS Registry Number	55268-75-2
SMILES	CON=C(C1=CC=CO1)C(=O)NC2C3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Rash papular	23.03.13.017	-	-	Not Available
Rash pruritic	23.03.13.030	0.000816%		Not Available
Renal failure	20.01.03.005	-	-	Not Available
Renal pain	20.02.03.003	-	-	Not Available
Respiratory arrest	22.02.01.009	0.000286%		Not Available
Respiratory distress	22.02.01.012	0.000143%		Not Available
Restlessness	19.11.02.002; 17.02.05.021	0.000744%
Retching	07.01.07.002	0.000501%		Not Available
Retinal degeneration	06.09.03.002	0.000286%		Not Available
Retinal detachment	12.01.04.004; 06.09.03.003	0.003076%
Retinal disorder	06.08.03.005	0.000286%		Not Available
Retinal haemorrhage	24.07.05.003; 06.10.01.001	0.001645%		Not Available
Retinal oedema	24.03.07.006; 06.04.06.007	0.001288%		Not Available
Retinal pigmentation	06.09.03.008	0.000730%		Not Available
Retinal vasculitis	10.02.02.021; 06.04.06.011	0.000143%		Not Available
Retinopathy	24.03.07.003; 06.10.02.001	0.000358%
Retinopathy proliferative	05.07.01.004; 24.03.07.010; 14.07.01.004; 06.10.02.005	0.000143%		Not Available
Salivary hypersecretion	07.06.01.009	0.000215%		Not Available
Seizure	17.12.03.001	-	-
Serum sickness-like reaction	10.01.03.005; 08.01.03.003	-	-	Not Available
Shock	24.06.02.002	0.000429%		Not Available
Sinusitis	22.07.03.007; 11.01.13.005	-	-
Skin discolouration	23.03.03.005	-	-	Not Available
Skin disorder	23.03.03.007	-	-	Not Available
Skin exfoliation	23.03.07.003	0.000386%		Not Available
Skin lesion	23.03.03.010	0.000501%		Not Available
Somnolence	19.02.05.003; 17.02.04.006	-	-
Speech disorder	17.02.08.003; 22.12.03.027; 19.19.02.002	0.000358%		Not Available
Sputum discoloured	22.02.03.010	0.000215%		Not Available
Stevens-Johnson syndrome	10.01.01.045; 23.03.01.007; 12.03.01.014; 11.07.01.005	0.000930%

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