Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ceftriaxone
Drug ID BADD_D00405
Description Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic.[A215582] It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges[A215582], eyes[A215647], and inner ear[A215627]. Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S.aureus. Ceftriaxone is a commonly used antimicrobial due to its good activity against multi-drug resistant Enterobacteriaceae, its relatively safe adverse effect profile, and its long half-life which allows for the convenience of daily or twice-daily dosing.[A215582]
Indications and Usage For the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
Marketing Status Prescription; Discontinued
ATC Code J01DD04
DrugBank ID DB01212
KEGG ID D07659
MeSH ID D002443
PubChem ID 5479530
TTD Drug ID D07ACT
NDC Product Code 66794-214; 71205-593; 68071-4713; 44567-702; 66794-215; 70518-3355; 68180-633; 0143-9859; 50090-0945; 63187-435; 66794-213; 64679-702; 64679-701; 25021-106; 0143-9678; 68180-622; 25021-105; 66794-212; 25021-107; 0264-3155; 44567-700; 64679-703; 66794-211; 44567-703; 0143-9856; 71205-117; 0143-9858; 68071-4715; 72572-061; 68180-611; 68071-4304; 64679-983; 68071-4303; 44567-701; 0264-3153; 0143-9857; 63323-346; 68180-644; 72572-062; 50090-2628
Synonyms Ceftriaxone | Ceftriaxon | Cefatriaxone | Ceftriaxone, Disodium Salt, Hemiheptahydrate | Ceftrex | Ceftriaxon Curamed | Ceftriaxon Hexal | Ceftriaxona Andreu | Ceftriaxona LDP Torlan | Ceftriaxone Irex | Ceftriaxone Sodium | Ceftriaxone Sodium, Anhydrous | Anhydrous Ceftriaxone Sodium | Lendacin | Longacef | Longaceph | Ro13-9904 | Ro13 9904 | Ro139904 | Ro-13-9904 | Ro 13-9904 | Ro 13 9904 | Ro 139904 | Rocephin | Rocefalin | Rocephine | Rocefin | Tacex | Terbac | Ceftriaxone, Disodium Salt | Benaxona | Cefaxona
Chemical Information
Molecular Formula C18H18N8O7S3
CAS Registry Number 73384-59-5
SMILES CN1C(=NC(=O)C(=O)N1)SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Serum sickness-like reaction08.01.03.003; 10.01.03.0050.040852%Not Available
Shock24.06.02.0020.183833%Not Available
Sinus bradycardia02.03.03.0090.020426%
Skin exfoliation23.03.07.0030.051065%Not Available
Skin infection23.09.04.002; 11.01.12.0030.005328%
Skin lesion23.03.03.0100.071490%Not Available
Skin necrosis23.03.03.0110.020426%Not Available
Somnolence17.02.04.006; 19.02.05.003--
Speech disorder22.02.05.034; 19.19.02.002; 17.02.08.003--Not Available
Spinal cord compression17.10.01.0060.030639%
Spinal cord injury17.10.04.001; 12.01.13.0020.030639%Not Available
Splenomegaly01.09.02.0010.005328%Not Available
Staring19.01.01.0030.020426%Not Available
Status epilepticus17.12.03.0050.132768%Not Available
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.0200.142981%
Stomatitis07.05.06.005--
Stridor22.04.02.0030.040852%
Stupor19.02.05.004; 17.02.04.0070.040852%Not Available
Subarachnoid haemorrhage24.07.04.004; 17.08.01.010; 12.01.10.0110.005328%Not Available
Sudden death08.04.01.003; 02.03.04.0130.005328%
Suffocation feeling22.02.08.0120.020426%Not Available
Superinfection11.01.08.009--Not Available
Swelling08.01.03.0150.071490%Not Available
Swelling face10.01.05.018; 23.04.01.0180.081703%Not Available
Swollen tongue10.01.05.015; 23.04.01.014; 07.14.02.0030.030639%Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.0080.194045%
Tachycardia02.03.02.0070.326813%Not Available
Tachypnoea22.02.01.0140.142981%Not Available
Tenderness08.01.08.005--Not Available
Tetany15.05.03.013; 14.04.01.005; 05.04.02.0030.051065%Not Available
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