Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ceftizoxime
Drug ID BADD_D00402
Description A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
Indications and Usage For the treatment of infections due to susceptible strains of microorganisms.
Marketing Status Discontinued
ATC Code J01DD07
DrugBank ID DB01332
KEGG ID D07658
MeSH ID D015296
PubChem ID 2655
TTD Drug ID D0Y7BD
NDC Product Code Not Available
Synonyms Ceftizoxime | Ceftizoxime Sodium | Sodium, Ceftizoxime | Ceftizoxime Monosodium Salt | Monosodium Salt, Ceftizoxime | Salt, Ceftizoxime Monosodium | SKF-88373 | SKF 88373 | SKF88373 | FR-13749 | FR 13749 | FR13749 | SK&F 88373-2 | SK&F 88373 2 | SK&F 883732 | Cefizox | FK749 | FK-749 | FK 749
Chemical Information
Molecular Formula C13H13N5O5S2
CAS Registry Number 68401-81-0
SMILES CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=CCS3)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Phlebitis24.05.03.001; 12.02.01.002--
Prothrombin level increased13.01.02.011--Not Available
Prothrombin time prolonged13.01.02.012--Not Available
Pruritus23.03.12.001--
Pseudomembranous colitis11.02.02.002; 07.19.01.003--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Seizure17.12.03.001--
Sensory loss17.02.07.007--Not Available
Serum sickness-like reaction10.01.03.005; 08.01.03.003--Not Available
Stevens-Johnson syndrome12.03.01.014; 11.07.01.005; 10.01.03.020; 23.03.01.007--
Tenderness08.01.08.005--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombocytosis01.08.02.001--Not Available
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006--
Vaginal infection21.14.02.002; 11.01.10.002--
Vaginal inflammation21.14.02.001--
Vomiting07.01.07.003--
Haemorrhage24.07.01.002--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Induration08.01.03.020--Not Available
Coombs test positive13.01.01.002--Not Available
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