Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Caspofungin acetate
Drug ID BADD_D00377
Description Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of the fungal cell wall.
Indications and Usage For the treatment of esophageal candidiasis and invasive aspergillosis in patients who are refractory to or intolerant of other therapies.
Marketing Status Prescription
ATC Code J02AX04
DrugBank ID DB00520
KEGG ID D02501
MeSH ID D000077336
PubChem ID 6850808
TTD Drug ID D00ZCN
NDC Product Code 63323-356; 0006-3822; 69097-366; 14474-037; 62227-022; 70860-107; 68083-159; 72611-702; 0781-3423; 68083-158; 69806-0092; 72843-533; 69097-365; 69766-064; 70860-106; 0006-3823; 63323-358; 72266-106; 57884-0030; 72843-434; 72266-107; 0781-3421; 52076-6230; 72611-700
Synonyms Caspofungin | Cancidas | MK 0991 | MK-0991 | MK0991 | Caspofungin MSD | L 743,872 | L-743,872 | L743,872 | L-743872 | L743872 | L 743872 | Caspofungin Acetate
Chemical Information
Molecular Formula C56H96N10O19
CAS Registry Number 179463-17-3
SMILES CCC(C)CC(C)CCCCCCCCC(=O)NC1CC(C(NC(=O)C2C(CCN2C(=O)C(NC(=O)C(NC(=O)C3CC(CN3C(=O) C(NC1=O)C(C)O)O)C(C(C4=CC=C(C=C4)O)O)O)C(CCN)O)O)NCCN)O.CC(=O)O.CC(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Myocardial infarction02.02.02.007; 24.04.04.009--
Nausea07.01.07.001--
Neutropenia01.02.03.004--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Pain in extremity15.03.04.010--
Pancreatitis07.18.01.001--
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.002--Not Available
Phlebitis24.05.03.001; 12.02.01.002--
Pleural effusion22.05.02.002--
Pneumonia11.01.09.003; 22.07.01.003--Not Available
Pyrexia08.05.02.003--
Rales22.02.04.004--Not Available
Rash23.03.13.001--Not Available
Red blood cells urine positive13.13.02.003--Not Available
Renal failure20.01.03.005--Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Seizure17.12.03.001--
Sepsis11.01.11.003--
Septic shock24.06.02.011; 11.01.11.004--Not Available
Skin exfoliation23.03.07.003--Not Available
Skin lesion23.03.03.010--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Swelling08.01.03.015--Not Available
Tachycardia02.03.02.007--Not Available
Tachypnoea22.02.01.014--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tremor17.01.06.002--
Urinary tract infection11.01.14.004; 20.08.02.001--
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