Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Caspofungin
Drug ID BADD_D00376
Description Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of the fungal cell wall.
Indications and Usage For the treatment of esophageal candidiasis and invasive aspergillosis in patients who are refractory to or intolerant of other therapies.
Marketing Status Prescription
ATC Code J02AX04
DrugBank ID DB00520
KEGG ID D07626
MeSH ID D000077336
PubChem ID 2826718
TTD Drug ID D00ZCN
NDC Product Code Not Available
Synonyms Caspofungin | Cancidas | MK 0991 | MK-0991 | MK0991 | Caspofungin MSD | L 743,872 | L-743,872 | L743,872 | L-743872 | L743872 | L 743872 | Caspofungin Acetate
Chemical Information
Molecular Formula C52H88N10O15
CAS Registry Number 162808-62-0
SMILES CCC(C)CC(C)CCCCCCCCC(=O)NC1CC(C(NC(=O)C2C(CCN2C(=O)C(NC(=O)C(NC(=O)C3CC(CN3C(=O) C(NC1=O)C(C)O)O)C(C(C4=CC=C(C=C4)O)O)O)C(CCN)O)O)NCCN)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Mucosal inflammation08.01.06.0020.000705%Not Available
Muscular weakness15.05.06.001; 17.05.03.005--
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Neoplasm16.16.02.001--Not Available
Neoplasm malignant16.16.01.001--Not Available
Nephropathy toxic20.05.03.002; 12.03.01.010--Not Available
Nervous system disorder17.02.10.001--Not Available
Neutropenia01.02.03.0040.000705%Not Available
Neutrophil count decreased13.01.06.010--
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Opportunistic infection11.01.08.007--Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005--
Pathogen resistance11.01.08.0490.000644%Not Available
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.002--Not Available
pH urine increased13.13.02.024--Not Available
Phlebitis24.05.03.001; 12.02.01.002--
Platelet count decreased13.01.04.001--
Pleural effusion22.05.02.0020.001057%
Pneumonia11.01.09.003; 22.07.01.0030.000735%Not Available
Protein total decreased13.09.01.004--Not Available
Prothrombin level increased13.01.02.011--Not Available
Prothrombin time shortened13.01.02.013--Not Available
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