Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carvedilol
Drug ID BADD_D00374
Description Carvedilol is a racemic mixture where the S(-) enantiomer is a beta adrenoceptor blocker and the R(+) enantiomer is both a beta and alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension.[A182306] Carvedilol was granted FDA approval on 14 September 1995.[L7889]
Indications and Usage For the treatment of mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.
Marketing Status Prescription; Discontinued
ATC Code C07AG02
DrugBank ID DB01136
KEGG ID D00255
MeSH ID D000077261
PubChem ID 2585
TTD Drug ID D0W9LX
NDC Product Code 71335-0368; 65862-142; 64220-150; 0615-8390; 50090-1856; 65691-0087; 61919-984; 68462-162; 43353-838; 63187-570; 68462-164; 68001-152; 0781-5222; 68001-154; 65862-145; 43063-125; 63187-409; 60760-234; 71335-1545; 71335-1407; 43353-874; 50090-2175; 71610-067; 68382-092; 68071-4470; 63187-424; 53104-7575; 51079-930; 61919-730; 65862-144; 70934-517; 68788-9789; 65841-617; 68071-3151; 70518-2389; 71335-0034; 70518-1377; 68071-4495; 35356-526; 61919-728; 63629-4070; 0615-8388; 42419-013; 68645-350; 72761-004; 55154-6883; 43353-837; 70934-406; 70518-0582; 0904-6300; 55154-5678; 72888-037; 68462-165; 51407-041; 0615-8387; 50090-1064; 55154-7278; 68071-4956; 70934-759; 70518-0356; 71610-066; 0904-6301; 63187-941; 43063-126; 50090-4898; 51655-397; 0093-7295; 68382-095; 70934-707; 51655-033; 65862-143; 51079-771; 51079-931; 61919-219; 55111-252; 68645-351; 70934-609; 68294-0005; 53002-1572; 60760-494; 76385-113; 50090-1069; 71335-1813; 68788-8151; 65841-618; 68001-151; 55111-255; 51407-039; 71335-2023; 57451-1155; 0904-6302; 0378-3633; 55154-6885; 60760-532; 71335-1533; 68788-7910; 52932-0726; 70934-515; 68071-4600; 68645-496; 47621-064; 0007-4140; 50090-2555; 0615-8018; 0093-7296; 63187-131; 68788-7883; 71335-2033; 68462-163; 71335-0561; 63187-946; 70786-0144; 42708-072; 0615-7946; 60760-235; 43353-832; 68788-7539; 55154-5676; 68071-4980; 76385-111; 50090-4171; 70934-910; 43063-833; 0615-8389; 61919-533; 53002-1574; 68084-854; 71610-132; 68788-7603; 50090-2119; 70518-0426; 68071-3078; 63629-4060; 51407-040; 55111-030; 53002-1573; 0781-5224; 0007-4141; 60760-233; 0904-6303; 76385-110; 70934-753; 68001-153; 60760-376; 68382-094; 70518-1826; 71335-2026; 70934-686; 0781-5221; 71335-1128; 0093-0051; 63187-447; 51407-042; 65862-369; 71335-1623; 53002-1556; 76385-112; 55111-254; 70934-211; 71610-062; 51079-932; 68071-2230; 50090-5115; 0378-3634; 50090-2066; 68382-093; 55154-6884; 68071-4974; 71335-1457; 68071-2633; 55700-819; 72888-034; 0615-7944; 71610-063; 0007-4142; 65841-619; 58118-0163; 0781-5223; 0378-3632; 68071-5275; 55154-5675; 66022-0120; 0007-4139; 55154-5677; 68788-7458; 71335-1937; 0378-3631; 0093-0135; 43063-129; 70934-516; 0615-7945; 62756-122; 55111-253; 71335-1463; 72888-035; 65841-616; 68788-9265; 70934-653; 68071-3269; 72888-036
Synonyms Carvedilol | Carvedilol Hydrochloride | Dilatrend | Querto | Eucardic | Carvedilol, (S)-isomer | Kredex | BM 14190 | BM-14190 | BM14190 | Carvedilol, (R)-isomer | Carvedilol, (+)-isomer | Carvedilol, (+) | Carvedilol, (+-)-isomer | Carvedilol, (-)-isomer | Carvedilol, (-) | Carvedilol, 14C-labeled | 14C-labeled Carvedilol | Carvedilol, 14C labeled | Coropres | Coreg
Chemical Information
Molecular Formula C24H26N2O4
CAS Registry Number 72956-09-3
SMILES COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T5739210772431; 15748098; 10983742
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
Atrioventricular block first degreeCytochrome P450 2D6P10635T57392Not Available
Atrioventricular block first degreeCytochrome P450 2D6P10635T5739210772431; 15748098; 10983742
Heart rate decreasedCytochrome P450 2D6P10635T5739210772431; 15748098; 10983742
Heart rate decreasedCytochrome P450 2D6P10635T57392Not Available
Left ventricular dysfunctionATP-dependent translocase ABCB1P08183T2525816800371; 12453548; 11738299
Vascular disordersMitogen-activated protein kinase 1P28482T5897026327764
Vascular disordersProto-oncogene tyrosine-protein kinase SrcP12931T8594326327764
Vascular disordersVascular endothelial growth factor receptor 2P35968T8097526327764
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Respiratory disorder22.02.07.002--Not Available
Respiratory distress22.02.01.012--Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.000148%
Restlessness19.11.02.002; 17.02.05.0210.000148%
Rhinitis22.07.03.006; 11.01.13.004--
Right ventricular failure02.05.03.0020.000026%Not Available
Seizure17.12.03.001--
Sepsis11.01.11.003--
Septic shock24.06.02.011; 11.01.11.0040.000026%Not Available
Shock24.06.02.0020.000639%Not Available
Sinus bradycardia02.03.03.0090.000492%
Sinus congestion22.04.06.001--Not Available
Sinus tachycardia02.03.03.0100.000148%
Sinusitis22.07.03.007; 11.01.13.005--
Skin disorder23.03.03.007--Not Available
Sleep disorder19.02.04.001--Not Available
Somnolence19.02.05.003; 17.02.04.0060.000344%
Stevens-Johnson syndrome12.03.01.014; 11.07.01.005; 10.01.03.020; 23.03.01.007--
Stomatitis07.05.06.005--
Sudden death08.04.01.003; 02.03.04.013--
Suicide attempt19.12.01.0040.000090%
Swelling08.01.03.015--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.0080.002016%
Tachycardia02.03.02.0070.000197%Not Available
Tension19.06.02.005--Not Available
Thinking abnormal19.10.03.001; 17.02.05.023--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Toxic epidermal necrolysis11.07.01.006; 10.01.01.006; 23.03.01.008; 12.03.01.015--
Tunnel vision17.17.01.013; 06.02.07.0050.000098%Not Available
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