Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carmustine
Drug ID BADD_D00371
Description A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Indications and Usage For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.
Marketing Status Prescription
ATC Code L01AD01
DrugBank ID DB00262
KEGG ID D00254
MeSH ID D002330
PubChem ID 2578
TTD Drug ID D01OXI
NDC Product Code 70121-1482; 50683-0017; 76339-121; 0781-3474; 59651-168; 24338-050; 68475-503; 54893-0055; 23155-649; 57821-002; 55718-139; 23155-790; 43598-628; 59981-034; 70710-1525; 58621-002; 57884-0032; 54879-036; 23155-261; 71288-126
Synonyms Carmustine | BCNU | N,N'-Bis(2-Chloroethyl)-N-Nitrosourea | FIVB | 1,3-Bis(2-Chloroethyl)-1-Nitrosourea | BiCNU | Nitrumon
Chemical Information
Molecular Formula C5H9Cl2N3O2
CAS Registry Number 154-93-8
SMILES C(CCl)NC(=O)N(CCCl)N=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
GliomaMethylated-DNA--protein-cysteine methyltransferaseP16455T2458711070098; 15297393; 12744471
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Renal injury20.01.03.015; 12.01.05.001--Not Available
Disease progression08.01.03.038--
Extradural abscess17.06.07.003; 11.01.03.0060.000799%Not Available
Neoplasm recurrence16.16.02.004--Not Available
Pulmonary toxicity22.01.02.007; 12.03.01.0130.000533%Not Available
Venoocclusive disease24.03.02.016--Not Available
Effusion08.01.03.052--Not Available
Idiopathic pneumonia syndrome22.01.02.015; 12.02.07.006--Not Available
Bone marrow failure01.03.03.005--
Post procedural infection12.02.05.010; 11.01.08.0190.000799%Not Available
Adverse reaction08.06.01.018--Not Available
Procedural haemorrhage12.02.05.036; 24.07.01.0530.000533%
Candida infection11.03.03.021--
Anal incontinence17.05.01.021; 07.01.06.029--
Subdural hygroma17.11.01.0180.000533%Not Available
Pneumocephalus17.02.05.060; 12.02.04.0090.005861%Not Available
Cerebral cyst17.18.05.002; 16.09.05.0020.000533%Not Available
Purulence11.01.08.0600.000799%Not Available
Brain midline shift17.11.01.0110.001066%Not Available
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