Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carmustine
Drug ID BADD_D00371
Description A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Indications and Usage For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.
Marketing Status Prescription
ATC Code L01AD01
DrugBank ID DB00262
KEGG ID D00254
MeSH ID D002330
PubChem ID 2578
TTD Drug ID D01OXI
NDC Product Code 70121-1482; 50683-0017; 76339-121; 0781-3474; 59651-168; 24338-050; 68475-503; 54893-0055; 23155-649; 57821-002; 55718-139; 23155-790; 43598-628; 59981-034; 70710-1525; 58621-002; 57884-0032; 54879-036; 23155-261; 71288-126
Synonyms Carmustine | BCNU | N,N'-Bis(2-Chloroethyl)-N-Nitrosourea | FIVB | 1,3-Bis(2-Chloroethyl)-1-Nitrosourea | BiCNU | Nitrumon
Chemical Information
Molecular Formula C5H9Cl2N3O2
CAS Registry Number 154-93-8
SMILES C(CCl)NC(=O)N(CCCl)N=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
GliomaMethylated-DNA--protein-cysteine methyltransferaseP16455T2458711070098; 15297393; 12744471
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Kidney small20.01.06.002--Not Available
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
Lung infiltration22.01.02.004--Not Available
Lymphopenia01.02.02.0020.000799%Not Available
Meningitis17.06.03.001; 11.01.03.0010.001598%
Meningitis bacterial17.06.10.002; 11.02.01.013--Not Available
Meningitis chemical17.06.03.003; 12.03.02.004--Not Available
Mental disability26.01.01.001--Not Available
Monoplegia17.01.04.003--Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Neck pain15.03.04.009--
Necrosis24.04.02.006; 08.03.03.001--Not Available
Neoplasm16.16.02.0010.000278%Not Available
Nephropathy toxic20.05.03.002; 12.03.01.010--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral08.01.07.007; 02.05.04.007; 14.05.06.011--
Optic neuritis06.04.08.002; 17.04.05.001; 10.04.10.002--Not Available
Oral candidiasis11.03.03.004; 07.05.07.001--Not Available
Osteomyelitis15.02.05.001; 11.01.01.0010.000533%
Pain08.01.08.004--
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.005--
Paralysis17.01.04.0040.002664%Not Available
Paranoia19.05.01.005--Not Available
The 4th Page    First    Pre   4 5 6 7    Next   Last    Total 7 Pages