Pharmaceutical Information |
Drug Name |
Carboprost tromethamine |
Drug ID |
BADD_D00366 |
Description |
A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of pregnancy. |
Indications and Usage |
For aborting pregnancy between the 13th and 20th weeks of gestation as calculated from the first day of the last normal menstrual period and in the following conditions related to second trimester abortion: 1. Failure of expulsion of the fetus during the course of treatment by another method; 2. Premature rupture of membranes in intrauterine methods with loss of drug and insufficient or absent uterine activity; 3. Requirement of a repeat intrauterine instillation of drug for expulsion of the fetus; 4. Inadvertent or spontaneous rupture of membranes in the presence of a previable fetus and absence of adequate activity for expulsion. Also for the treatment of postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management. |
Marketing Status |
Prescription |
ATC Code |
G02AD04 |
DrugBank ID |
DB00429
|
KEGG ID |
D00682
|
MeSH ID |
C062843
|
PubChem ID |
5281074
|
TTD Drug ID |
D07PCI
|
NDC Product Code |
68245-0016; 69784-240; 82231-103; 54893-0023; 43598-917; 70121-1680; 43598-698; 0009-0856; 43598-919 |
Synonyms |
carboprost tromethamine | carboprost trometamol | 15-methylprostaglandin F2alpha-tromethamine | Hemabate | Prostin M-15 |
|
Chemical Information |
Molecular Formula |
C25H47NO8 |
CAS Registry Number |
58551-69-2 |
SMILES |
CCCCCC(C)(C=CC1C(CC(C1CC=CCCCC(=O)O)O)O)O.C(C(CO)(CO)N)O |
Chemical Structure |
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ADR Related Proteins Induced by Drug |
ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
Not Available | Not Available | Not Available | Not Available | Not Available |
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ADRs Induced by Drug |
ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
Vomiting | 07.01.07.003 | - | - | | Wheezing | 22.03.01.009 | - | - | | Uterine cyst | 21.07.02.007; 16.04.02.003 | - | - | Not Available | Hot flush | 21.02.02.001; 08.01.03.027; 24.03.01.005 | - | - | | Perforation | 08.01.03.058 | - | - | Not Available |
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