Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carboprost
Drug ID BADD_D00365
Description A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of pregnancy.
Indications and Usage For aborting pregnancy between the 13th and 20th weeks of gestation as calculated from the first day of the last normal menstrual period and in the following conditions related to second trimester abortion: 1. Failure of expulsion of the fetus during the course of treatment by another method; 2. Premature rupture of membranes in intrauterine methods with loss of drug and insufficient or absent uterine activity; 3. Requirement of a repeat intrauterine instillation of drug for expulsion of the fetus; 4. Inadvertent or spontaneous rupture of membranes in the presence of a previable fetus and absence of adequate activity for expulsion. Also for the treatment of postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management.
Marketing Status Not Available
ATC Code G02AD04
DrugBank ID DB00429
KEGG ID D02343
MeSH ID D002260
PubChem ID 5281075
TTD Drug ID Not Available
NDC Product Code 43598-917; 0009-0856; 54893-0023; 68245-0016; 70121-1680; 82231-103; 43598-698; 69784-240; 43598-919
Synonyms Carboprost | 15-Methylprostaglandin F2alpha | 15 Methylprostaglandin F2alpha | 15(S)-15-Methyl PGF2alpha
Chemical Information
Molecular Formula C21H36O5
CAS Registry Number 35700-23-3
SMILES CCCCCC(C)(C=CC1C(CC(C1CC=CCCCC(=O)O)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain upper07.01.05.003--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema10.01.05.009; 23.04.01.001--Not Available
Anxiety19.06.02.002--
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Back pain15.03.04.005--
Body temperature increased13.15.01.001--Not Available
Breast tenderness21.05.05.004--Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Choking22.02.05.001--Not Available
Cough22.02.03.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry throat07.06.01.005; 22.02.05.004--Not Available
Dysmenorrhoea21.01.01.002--
Dyspnoea22.02.01.004; 02.01.03.002--
Endometritis21.14.01.002; 11.01.10.005--Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Eye pain06.08.03.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Haematemesis24.07.02.011; 07.12.02.002--Not Available
Headache17.14.01.001--
Hiccups22.02.04.002; 07.01.06.009--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
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