Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carboplatin
Drug ID BADD_D00364
Description Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.[L32253] Early clinical studies of carboplatin were performed in 1982.[A230523] Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]
Indications and Usage For the initial treatment of advanced ovarian carcinoma in established combination with other approved chemotherapeutic agents. One established combination regimen consists of PARAPLATIN and cyclophosphamide. It is also indicated for the palliative treatment of patients with ovarian carcinoma recurrent after prior chemotherapy, including patients who have been previously treated with cisplatin.
Marketing Status Prescription; Discontinued
ATC Code L01XA02
DrugBank ID DB00958
KEGG ID D01363
MeSH ID D016190
PubChem ID 426756
TTD Drug ID D0X7HM
NDC Product Code 0703-4239; 55150-335; 63592-0271; 68083-192; 49812-0010; 68554-0084; 53104-7570; 69448-005; 0703-4246; 54875-0002; 55150-386; 55150-334; 0703-4248; 55150-333; 63323-172; 72659-863; 68083-191; 71288-100; 16729-295; 0703-4244; 68083-193; 68083-190; 61703-339
Synonyms Carboplatin | cis-Diammine(cyclobutanedicarboxylato)platinum II | CBDCA | Paraplatin | Paraplatine | Platinwas | Ribocarbo | Carboplat | Neocarbo | Carbosin | Carbotec | Ercar | JM-8 | JM 8 | JM8 | Nealorin | NSC-241240 | NSC 241240 | NSC241240 | Blastocarb
Chemical Information
Molecular Formula C6H12N2O4Pt
CAS Registry Number 41575-94-4
SMILES C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Optic atrophy06.09.02.0010.001066%Not Available
Oral candidiasis11.03.03.004; 07.05.07.0010.000799%Not Available
Oral discomfort07.05.05.0010.000799%Not Available
Oral pain07.05.03.0020.001332%
Osteoarthritis15.01.04.001--Not Available
Osteomyelitis15.02.05.001; 11.01.01.0010.000799%
Ototoxicity12.03.01.012; 04.03.01.0040.001066%Not Available
Ovarian cancer21.11.01.003; 16.12.04.0010.000278%Not Available
Oxygen saturation decreased13.02.01.0040.015185%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pain in jaw15.02.01.003--Not Available
Pallor24.03.04.001; 23.03.03.031; 08.01.03.0320.003197%Not Available
Palmar erythema23.03.06.0100.002398%Not Available
Palmar-plantar erythrodysaesthesia syndrome23.07.04.001; 17.02.07.0090.003463%
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Pancreatitis acute07.18.01.002--Not Available
Pancytopenia01.03.03.0030.024243%Not Available
Papilloedema17.07.02.004; 24.03.07.001; 06.09.02.0020.002131%
Paraesthesia17.02.06.0050.010656%
Parathyroid disorder05.04.03.0010.000533%Not Available
Paresis17.01.04.0080.000533%Not Available
Pelvic abscess11.01.08.025; 21.10.03.0060.000799%Not Available
Pelvic pain21.10.01.001; 20.02.03.007; 07.01.06.0120.001598%
Pelvic venous thrombosis24.01.02.0080.000533%Not Available
Pemphigoid23.03.01.004; 10.04.02.0020.000533%Not Available
Pericarditis02.06.02.0010.001598%
Peripheral coldness24.04.03.006; 08.01.09.0100.000533%Not Available
Peripheral ischaemia24.04.03.0020.002398%
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