Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Carboplatin
Drug ID BADD_D00364
Description Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.[L32253] Early clinical studies of carboplatin were performed in 1982.[A230523] Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]
Indications and Usage Carboplatin is indicated in combination with an established combination of chemotherapeutic agents for the initial treatment of advanced ovarian carcinoma.[L32253] Carboplatin is also indicated for the palliative treatment of ovarian carcinoma, recurrent after prior chemotherapy.[L32253]
Marketing Status approved
ATC Code L01XA02
DrugBank ID DB00958
KEGG ID D01363
MeSH ID D016190
PubChem ID 426756
TTD Drug ID D0X7HM
NDC Product Code 0703-4239; 55150-386; 63323-172; 68083-191; 63592-0271; 61703-339; 0703-4244; 0703-4246; 72659-863; 50742-447; 69448-005; 61703-600; 55150-334; 61703-262; 61703-360; 71288-100; 49812-0010; 16729-295; 55150-333; 61703-150; 68083-193; 68554-0084; 68083-190; 68083-192; 53104-7570; 54875-0002; 50742-448; 55150-335; 0703-4248
UNII BG3F62OND5
Synonyms Carboplatin | cis-Diammine(cyclobutanedicarboxylato)platinum II | CBDCA | Paraplatin | Paraplatine | Platinwas | Ribocarbo | Carboplat | Neocarbo | Carbosin | Carbotec | Ercar | JM-8 | JM 8 | JM8 | Nealorin | NSC-241240 | NSC 241240 | NSC241240 | Blastocarb
Chemical Information
Molecular Formula C6H12N2O4Pt
CAS Registry Number 41575-94-4
SMILES C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rash papular23.03.13.0170.000280%Not Available
Rash pruritic23.03.13.0300.000672%Not Available
Raynaud's phenomenon24.04.03.0030.000168%Not Available
Renal failure20.01.03.0050.002183%Not Available
Renal tubular disorder20.05.03.0040.000224%Not Available
Renal tubular necrosis20.01.07.0030.000392%Not Available
Respiratory acidosis22.02.02.004; 14.01.04.0020.000168%Not Available
Respiratory arrest22.02.01.0090.000672%Not Available
Respiratory disorder22.02.07.0020.000783%Not Available
Respiratory distress22.02.01.0120.001925%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.002854%
Restlessness19.11.02.002; 17.02.05.0210.000582%
Retching07.01.07.0020.000839%Not Available
Retinal artery occlusion24.01.07.003; 06.10.01.0050.000224%Not Available
Retinal detachment12.01.04.004; 06.09.03.0030.000168%
Retinal disorder06.08.03.0050.000112%Not Available
Retinal haemorrhage24.07.05.003; 06.10.01.0010.000504%Not Available
Sarcoidosis10.02.06.0010.000112%Not Available
Scleroderma23.03.02.005; 15.06.01.002; 10.04.07.0010.000112%Not Available
Second primary malignancy16.16.01.0140.000728%
Sense of oppression08.01.09.0200.000839%Not Available
Sensory disturbance17.02.07.006--Not Available
Sensory loss17.02.07.0070.000168%Not Available
Shock24.06.02.0020.001679%Not Available
Sinus tachycardia02.03.03.0100.000280%
Skin discolouration23.03.03.005--Not Available
Skin disorder23.03.03.007--Not Available
Skin hyperpigmentation23.05.01.0030.000168%
Skin lesion23.03.03.0100.000392%Not Available
Skin reaction23.03.03.013; 10.01.03.0190.001511%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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