Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carboplatin
Drug ID BADD_D00364
Description Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.[L32253] Early clinical studies of carboplatin were performed in 1982.[A230523] Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]
Indications and Usage For the initial treatment of advanced ovarian carcinoma in established combination with other approved chemotherapeutic agents. One established combination regimen consists of PARAPLATIN and cyclophosphamide. It is also indicated for the palliative treatment of patients with ovarian carcinoma recurrent after prior chemotherapy, including patients who have been previously treated with cisplatin.
Marketing Status Prescription; Discontinued
ATC Code L01XA02
DrugBank ID DB00958
KEGG ID D01363
MeSH ID D016190
PubChem ID 426756
TTD Drug ID D0X7HM
NDC Product Code 0703-4239; 55150-335; 63592-0271; 68083-192; 49812-0010; 68554-0084; 53104-7570; 69448-005; 0703-4246; 54875-0002; 55150-386; 55150-334; 0703-4248; 55150-333; 63323-172; 72659-863; 68083-191; 71288-100; 16729-295; 0703-4244; 68083-193; 68083-190; 61703-339
Synonyms Carboplatin | cis-Diammine(cyclobutanedicarboxylato)platinum II | CBDCA | Paraplatin | Paraplatine | Platinwas | Ribocarbo | Carboplat | Neocarbo | Carbosin | Carbotec | Ercar | JM-8 | JM 8 | JM8 | Nealorin | NSC-241240 | NSC 241240 | NSC241240 | Blastocarb
Chemical Information
Molecular Formula C6H12N2O4Pt
CAS Registry Number 41575-94-4
SMILES C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Myelitis17.06.02.001; 11.01.03.0070.000533%
Myelodysplastic syndrome16.01.04.001; 01.10.04.0010.001181%
Myocardial infarction02.02.02.007; 24.04.04.009--
Myocardial ischaemia24.04.04.010; 02.02.02.008--Not Available
Myoclonus17.02.05.0080.001066%Not Available
Myositis15.05.01.0010.002131%
Nasal congestion22.04.04.001--
Nausea07.01.07.0010.066603%
Neck pain15.03.04.009--
Necrosis24.04.02.006; 08.03.03.001--Not Available
Neoplasm16.16.02.0010.000208%Not Available
Neoplasm malignant16.16.01.001--Not Available
Nephritis20.05.02.0010.001332%Not Available
Nephrolithiasis20.04.01.002--
Nephropathy toxic20.05.03.002; 12.03.01.0100.000799%Not Available
Nervous system disorder17.02.10.001--Not Available
Neuralgia17.02.07.0050.000799%
Neuropathy peripheral17.09.03.0030.009591%Not Available
Neurotoxicity17.02.10.002; 12.03.01.0110.001598%Not Available
Neutropenia01.02.03.0040.041294%Not Available
Neutrophil count decreased13.01.06.0100.022112%
Neutrophil count increased13.01.06.011--Not Available
Odynophagia07.05.03.0010.001865%Not Available
Oedema14.05.06.010; 08.01.07.0060.002931%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oesophageal carcinoma16.13.06.001; 07.21.06.0010.000139%Not Available
Oesophageal pain07.01.05.0120.001066%
Oesophageal stenosis07.13.02.0010.001332%
Oesophageal ulcer07.04.05.0020.000533%
Oesophagitis07.08.05.0010.004529%
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