Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Capecitabine
Drug ID BADD_D00349
Description Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Indications and Usage For the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen. May also be used in combination with docetaxel for the treatment of metastatic breast cancer in patients who have failed to respond to, or recurred or relasped during or following anthracycline-containing chemotherapy. Capecitabine is used alone as an adjuvant therapy following the complete resection of primary tumor in patients with stage III colon cancer when monotherapy with fluroprymidine is preferred. The use or capecitabine in combination regimens for advanced gastric cancer is currently being investigated.
Marketing Status Prescription
ATC Code L01BC06
DrugBank ID DB01101
KEGG ID D01223
MeSH ID D000069287
PubChem ID 60953
TTD Drug ID D00HCQ
NDC Product Code 72205-007; 69097-948; 59923-722; 59651-204; 0378-2511; 55111-893; 55111-496; 0054-0272; 72205-006; 70756-816; 50268-154; 51407-095; 15308-0714; 16714-467; 62756-239; 67877-458; 64980-277; 55512-0015; 16729-072; 68001-487; 67877-459; 55111-497; 51079-510; 35369-0010; 54893-0002; 70756-815; 63482-099; 60687-149; 0004-1101; 62331-043; 72485-205; 53183-4009; 69539-019; 0004-1100; 65162-843; 16729-073; 72969-094; 62756-238; 16714-468; 68554-0033; 69097-949; 54245-7014; 72485-204; 62756-088; 0054-0271; 59651-205; 0093-7473; 72606-555; 76302-001; 69539-020; 65162-844; 53104-7618; 0378-2512; 51407-096; 81955-0001; 63759-0001; 49452-1713; 68001-488; 65129-1241; 64980-276; 0093-7474; 72606-554; 59923-721
Synonyms Capecitabine | N(4)-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine | Xeloda
Chemical Information
Molecular Formula C15H22FN3O6
CAS Registry Number 154361-50-9
SMILES CCCCCOC(=O)NC1=NC(=O)N(C=C1F)C2C(C(C(O2)C)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypoxia22.02.02.003--
Ileal perforation07.04.06.0100.000533%
Ileal ulcer07.04.06.0080.001332%
Ileus07.13.01.0010.004263%
Ileus paralytic07.02.05.0010.001332%Not Available
Immune system disorder10.02.01.001--Not Available
Impaired gastric emptying07.02.02.0040.000533%
Impetigo23.09.01.006; 11.01.12.0060.000533%Not Available
Incisional hernia12.02.05.017; 07.16.04.001--Not Available
Incoherent19.10.03.006; 17.02.08.0020.000533%Not Available
Incontinence20.02.02.004; 17.05.01.006; 07.01.06.011--Not Available
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Infection11.01.08.0020.003405%Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Influenza like illness08.01.03.010--
Inguinal hernia07.16.02.0010.000533%Not Available
Injection site infection12.07.03.008; 11.01.08.005; 08.02.03.019--Not Available
Injection site pain08.02.03.010; 12.07.03.011--Not Available
Injection site reaction12.07.03.015; 08.02.03.014--
Insomnia19.02.01.002; 17.15.03.002--
Interstitial lung disease10.02.01.033; 22.01.02.0030.006660%Not Available
Intertrigo23.03.04.028--Not Available
Intestinal dilatation07.02.02.0100.001066%Not Available
Intestinal ischaemia24.04.08.001; 07.15.02.0010.000556%Not Available
Intestinal obstruction07.13.01.0020.011988%Not Available
Intestinal perforation07.04.06.0020.003197%Not Available
Intravascular haemolysis01.06.04.0080.000533%Not Available
Irritability08.01.03.011; 19.04.02.013--
Jaundice23.03.03.030; 01.06.04.004; 09.01.01.0040.004529%Not Available
Joint stiffness15.01.02.0030.002131%Not Available
The 13th Page    First    Pre   13 14 15 16 17    Next   Last    Total 35 Pages