Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Caffeine citrate
Drug ID BADD_D00333
Description Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine].[A187691,L9851] It can be sourced from coffee beans, but also occurs naturally in various teas and cacao beans, which are different than coffee beans.[T716] Caffeine is also used in a variety of cosmetic products and can be administered topically, orally, by inhalation, or by injection.[T716] The caffeine citrate injection, used for apnea of the premature newborn, was initially approved by the FDA in 1999.[L9863] According to an article from 2017, more than 15 million babies are born prematurely worldwide. This correlates to about 1 in 10 births. Premature birth can lead to apnea and bronchopulmonary dysplasia, a condition that interferes with lung development and may eventually cause asthma or early onset emphysema in those born prematurely.[A187694] Caffeine is beneficial in preventing and treating apnea and bronchopulmonary dysplasia in newborns, improving the quality of life of premature infants.[T716]
Indications and Usage For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
Marketing Status Prescription
ATC Code D11AX26; N06BC01
DrugBank ID DB00201
KEGG ID D07603
MeSH ID C026189
PubChem ID 6241
TTD Drug ID Not Available
NDC Product Code 72485-110; 51754-0501; 63323-407; 42571-244; 51754-0500; 51754-0503; 0641-6164; 63323-406; 42571-346; 51754-0502; 0517-0020; 72485-104; 25021-602; 47335-290; 25021-601; 55150-187; 47335-289
Synonyms caffeine citrate | Cafcit
Chemical Information
Molecular Formula C14H18N4O9
CAS Registry Number 69-22-7
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood calcium increased13.11.01.003--Not Available
Blood glucose abnormal13.02.02.008--Not Available
Blood sodium increased13.11.01.013--Not Available
Cerebral haemorrhage24.07.04.001; Available
Creatinine renal clearance increased13.13.01.015--Not Available
Disseminated intravascular coagulation24.01.01.010;
Dry skin23.03.03.001--
Feeling jittery08.01.09.016--Not Available
Gastrointestinal haemorrhage24.07.02.009; Available
Gastrointestinal stenosis07.13.01.007--Not Available
Impaired healing08.03.02.001--Not Available
Injury12.01.08.004--Not Available
Pulmonary oedema22.01.03.003;
Rash23.03.13.001--Not Available
Renal failure20.01.03.005--Not Available
Retinopathy of prematurity18.04.01.004;; Available
Skin disorder23.03.03.007--Not Available
Stroke volume increased13.14.02.004--Not Available
Tachycardia02.03.02.007--Not Available
Urine flow decreased20.02.02.012--Not Available
Increased ventricular afterload13.14.02.014--Not Available
Necrotising colitis07.08.01.013--Not Available
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