Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Buspirone hydrochloride
Drug ID BADD_D00317
Description Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class,[A180991] buspirone is a serotonin 5-HT1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs.[L4478] Unlike many drugs used to treat anxiety, buspirone does not exhibit anticonvulsant, sedative, hypnotic, and muscle-relaxant properties. Due to these characteristics, buspirone been termed 'anxioselective'.[A180985] First synthesized in 1968 then patented in 1975,[L7375] it is commonly marketed under the brand name Buspar®. Buspirone was first approved in 1986 by the FDA [A181751] and has been used to treat anxiety disorders, such as generalized anxiety disorder (GAD), and relieve symptoms of anxiety. It has also been used as a second-line therapy for unipolar depression when the use of selective serotonin reuptake inhibitors (SSRIs) is deemed clinically inadequate or inappropriate.[L7375] The potential use of buspirone in combination with [melatonin] in depression and cognitive impairment via promoting neurogenesis has also been investigated.[A181751]
Indications and Usage For the management of anxiety disorders or the short-term relief of the symptoms of anxiety, and also as an augmention of SSRI-treatment against depression.
Marketing Status Prescription; Discontinued
ATC Code N05BE01
DrugBank ID DB00490
KEGG ID D00702
MeSH ID D002065
PubChem ID 36431
TTD Drug ID D0U2OO
NDC Product Code 63187-221; 71335-1560; 70518-1050; 71335-1673; 55111-472; 63629-2409; 42291-176; 29300-244; 29300-247; 63187-402; 71610-342; 50090-2111; 50090-5347; 42806-082; 70518-3165; 29300-246; 71610-604; 68071-2572; 50090-4862; 70518-3065; 71335-1749; 50090-4182; 42806-085; 59651-393; 42806-662; 64380-742; 24689-785; 72888-063; 68788-7571; 68788-7462; 23155-097; 64380-743; 50090-5762; 0378-1150; 75834-270; 71335-1752; 70934-327; 42543-742; 68382-181; 55111-474; 51407-378; 69584-093; 55700-881; 43063-785; 71335-1608; 69238-1117; 29300-245; 63629-2411; 63629-3333; 55700-869; 63187-904; 50090-5405; 64380-787; 71610-299; 71610-208; 61919-579; 59651-392; 68382-183; 70518-0682; 68382-182; 0904-6899; 53747-040; 71610-640; 55700-526; 69117-0041; 63629-2414; 72888-066; 70518-1530; 0093-0053; 64380-744; 0615-7718; 42806-665; 70518-2303; 68788-7885; 51079-960; 70518-1924; 63629-6817; 50268-135; 70518-1404; 42543-744; 69238-1118; 55154-5397; 24689-907; 59651-389; 72789-141; 63629-6818; 42806-083; 64380-741; 50090-5797; 75834-267; 55154-5494; 16729-203; 24689-921; 65841-784; 69238-1116; 50090-3168; 53808-1102; 0615-7714; 63629-2413; 68788-8086; 51407-414; 51407-417; 69584-092; 63187-645; 23155-024; 0378-1140; 70518-0680; 59651-390; 71610-203; 71335-0991; 70518-2724; 51407-201; 51407-202; 71610-267; 71610-596; 51407-203; 12780-2940; 71610-344; 51407-377; 53002-1017; 55111-473; 63629-2410; 63629-2412; 60760-548; 71610-206; 49884-725; 69117-0042; 51407-415; 55111-475; 70518-2803; 53002-1424; 16729-202; 58118-0742; 71205-493; 50090-5886; 69117-0043; 42543-743; 70518-2987; 70934-198; 70518-0681; 0093-1003; 51079-986; 71335-0222; 70518-3091; 70518-2977; 61919-166; 67296-1520; 50090-5136; 70934-426; 50090-3260; 53002-5017; 71335-0562; 42291-177; 72789-142; 0378-1165; 68788-7968; 72789-181; 70518-3279; 59651-391; 63629-2415; 71610-302; 68788-7017; 0093-0054; 72189-175; 65841-782; 69584-094; 42543-787; 70518-2300; 70518-0380; 70934-184; 42806-084; 42806-664; 0093-5200; 70518-2031; 16729-200; 63629-7277; 75834-268; 23155-025; 0904-7121; 68071-3229; 51079-985; 43353-060; 71610-291; 24689-933; 71610-165; 71335-1938; 55154-3364; 42806-086; 70518-2830; 68788-7875; 72888-062; 50090-4657; 71205-280; 24689-781; 71335-1105; 68788-7952; 51927-3399; 72888-065; 69584-091; 70518-2660; 71610-487; 50090-4859; 0904-7122; 69238-1119; 70518-0401; 71335-1930; 72789-140; 71335-1144; 49452-1310; 16729-289; 69238-1115; 71335-2060; 67046-558; 63629-2408; 71335-0272; 0378-1145; 71610-307; 55700-837; 0378-1175; 71610-281; 68382-180; 67296-0925; 71610-266; 70518-2591; 71335-0552; 65841-783; 68071-3336; 75834-266; 68788-6984; 23155-023; 69117-0040; 71610-360; 42806-663; 71610-404; 72888-064; 42543-741; 71610-183; 70518-1981; 50090-5614; 51079-994; 51407-413; 51407-416; 55700-937; 71335-1924; 71335-1390; 65841-781; 0615-7689; 71335-0985; 71335-1605; 71610-608; 72789-139; 72189-200; 16729-201; 51927-0169; 70518-3382; 75834-269; 71610-257
Synonyms Buspirone | N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1-cyclopentanediacetamide | Buspirone Hydrochloride | Hydrochloride, Buspirone | Gen-Buspirone | Gen Buspirone | Lin-Buspirone | Lin Buspirone | MJ-9022-1 | MJ 9022 1 | MJ90221 | Neurosine | Busp | Nu-Buspirone | Nu Buspirone | PMS-Buspirone | PMS Buspirone | Ratio-Buspirone | Ratio Buspirone | Anxut | Apo-Buspirone | Apo Buspirone | Buspar | Bespar | Novo-Buspirone | Novo Buspirone
Chemical Information
Molecular Formula C21H32ClN5O2
CAS Registry Number 33386-08-2
SMILES C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Acne23.02.01.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Akathisia19.06.02.006; 17.01.02.002--
Alanine aminotransferase increased13.03.01.003--
Alcohol abuse19.07.02.007--Not Available
Alopecia23.02.02.001--
Amenorrhoea21.01.02.001; 05.05.01.002--
Anger19.04.02.001--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Aphonia22.02.05.024; 19.19.01.002; 17.02.08.009--
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.01.006--
Ataxia17.02.02.001; 08.01.02.004--
Blister12.01.06.002; 23.03.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardiomyopathy02.04.01.001--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.003--Not Available
Chorea17.01.01.001--Not Available
Chromatopsia06.02.05.001--Not Available
Claustrophobia19.06.03.005--Not Available
Cogwheel rigidity17.01.05.001; 15.05.04.006--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis11.01.06.012; 06.04.01.002--
Decreased interest19.15.02.004--Not Available
Depression19.15.01.001--
Dissociative disorder19.14.01.003--Not Available
Disturbance in attention19.21.02.002; 17.03.03.001--
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