Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bromhexine
Drug ID BADD_D00302
Description Bromhexine is mucolytic agent used for a variety of respiratory conditions associated with increased mucus secretion. It is derived from the Adhatoda vasica plant and aids in the clearance of excess mucus, improving breathing and reducing cough. It was introduced into the market in 1963, and is widely available as an over-the-counter drug in many countries.[A233240] Recently, bromhexine and its metabolite [ambroxol] have garnered interest for the potential prevention and treatment of COVID-19 due to their interactions with cell receptors in the lungs.[A233345,A233370]
Indications and Usage
Marketing Status Not Available
ATC Code R05CB02
DrugBank ID DB09019
KEGG ID D07542
MeSH ID D001964
PubChem ID 2442
TTD Drug ID D07UWJ
NDC Product Code Not Available
Synonyms Bromhexine | Aparsonin | Bromhexin BC | BC, Bromhexin | Bromhexin Berlin-Chemie | Bromhexin Berlin Chemie | Bromhexin BerlinChemie | Bromhexine Hydrochloride | Hydrochloride, Bromhexine | Bromhexine Monohydrochloride | Monohydrochloride, Bromhexine | Brotussol | bromhexin von ct | ct, bromhexin von | von ct, bromhexin | Darolan | Dur-Elix | Dur Elix | DurElix | Famel Bromhexine | Bromhexine, Famel | Flegamin | Flubron | Hustentabs-ratiopharm | Hustentabs ratiopharm | Hustentabsratiopharm | Bromhexin-ratiopharm | Bromhexin ratiopharm | Bromhexinratiopharm | Mucohexine | NA-274 | NA 274 | NA274 | Tesacof | Bisolvon | Quentan | Bromhexin
Chemical Information
Molecular Formula C14H20Br2N2
CAS Registry Number 3572-43-8
SMILES CN(CC1=C(C(=CC(=C1)Br)Br)N)C2CCCCC2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain upper07.01.05.003--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Gastrointestinal disorder07.11.01.001--Not Available
Hypersensitivity10.01.03.003--
Immune system disorder10.02.01.001--Not Available
Nausea07.01.07.001--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Skin disorder23.03.03.007--Not Available
Urticaria10.01.06.001; 23.04.02.001--
Vomiting07.01.07.003--
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