Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bosutinib
Drug ID BADD_D00286
Description Bosutinib is a Bcr-Abl kinase inhibitor for the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Compared to other tyrosine kinase inhibitors, it has a more favourable hematologic toxicity profile. FDA approved on September 4, 2012.
Indications and Usage Treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) with resistance or intolerance to prior therapy in adult patients.
Marketing Status Not Available
ATC Code L01EA04
DrugBank ID DB06616
KEGG ID D03252
MeSH ID C471992
PubChem ID 5328940
TTD Drug ID D0OB0F
NDC Product Code 54893-0042; 54893-0048; 54893-0041; 46708-878
Synonyms bosutinib | SKI606 | SKI-606
Chemical Information
Molecular Formula C26H29Cl2N5O3
CAS Registry Number 380843-75-4
SMILES CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastroenteritis viral11.05.04.005; 07.19.03.0050.000533%Not Available
Gastrointestinal disorder07.11.01.0010.003730%Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.0050.000533%
Gout15.01.06.001; 14.09.01.0010.000533%Not Available
Haematochezia24.07.02.012; 07.12.02.0030.001332%Not Available
Blood urine present13.13.02.0020.000533%Not Available
Haemoglobin decreased13.01.05.0030.005328%Not Available
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.006--Not Available
Haemorrhoids07.15.03.001; 24.10.02.0020.000533%
Headache17.14.01.0010.015452%
Heart rate increased13.14.04.0020.001332%Not Available
Hepatic cirrhosis09.01.04.0010.000139%Not Available
Hepatic failure09.01.03.002--
Hepatic function abnormal09.01.02.0010.002131%Not Available
Hepatitis09.01.07.004--Not Available
Hepatitis toxic12.03.01.016; 09.01.07.017--Not Available
Hepatocellular injury09.01.07.0080.000799%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.001598%Not Available
Herpes virus infection11.05.02.0080.000533%Not Available
Herpes zoster23.09.03.002; 11.05.02.003--
Hyperaesthesia17.02.06.0040.000533%Not Available
Hypercalcaemia14.04.01.003; 05.04.01.0020.000533%
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkalaemia14.05.03.001--
Hypersensitivity10.01.03.003--
Hypersomnia19.02.05.001; 17.15.01.0010.000533%
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
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