Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bosentan
Drug ID BADD_D00285
Description Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.
Indications and Usage Used in the treatment of pulmonary arterial hypertension (PAH), to improve exercise ability and to decrease the rate of clinical worsening (in patients with WHO Class III or IV symptoms).
Marketing Status Prescription
ATC Code C02KX01
DrugBank ID DB00559
KEGG ID D01227
MeSH ID D000077300
PubChem ID 104865
TTD Drug ID D0U4CE
NDC Product Code 68382-447; 68180-387; 46708-881; 65162-873; 49884-058; 66215-103; 0054-0521; 65162-874; 0591-2512; 47781-271; 65015-770; 66215-101; 68382-446; 49884-059; 53104-7703; 47335-039; 0054-0520; 82245-0104; 0591-2511; 14501-0041; 66215-232; 47335-038; 70771-1018; 66215-102; 70771-1017; 66039-870; 47781-270; 68180-386; 65015-753
Synonyms Bosentan | 4-t-Butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide | Bosentan Monohydrate | Tracleer | Bosentan Anhydrous | Ro 47-0203 | Ro 47 0203 | Ro 470203 | Ro-47-0203
Chemical Information
Molecular Formula C27H29N5O6S
CAS Registry Number 147536-97-8
SMILES CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=NC=CC=N3)OCCO)OC4=CC=CC=C4OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HyperphosphatasaemiaBile salt export pumpO95342T3396911309550; 12127422; 11557132
Liver disorderEndothelin-1P05305T2507610564099; 11230754; 12713865; 15185300
Liver disorderNitric oxide synthase, endothelialP29474T0604610564099; 11230754; 12713865; 15185300
Liver injuryBile salt export pumpO95342T3396911309550; 12127422; 11557132
Lung disorderNitric oxide synthase, endothelialP29474T0604610564099; 11230754; 12713865; 15185300
Lung disorderEndothelin-1P05305T2507610564099; 11230754; 12713865; 15185300
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.006707%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.023026%Not Available
Chills15.05.03.016; 08.01.09.001--
Choking22.02.05.0010.001118%Not Available
Choking sensation22.02.05.002; 19.01.02.0020.000447%Not Available
Cholangitis09.02.01.0020.000671%Not Available
Cholecystitis09.03.01.0010.002459%
Cholecystitis acute09.03.01.0030.000447%Not Available
Cholelithiasis09.03.01.0020.004024%Not Available
Cholestasis09.01.01.001--Not Available
Chromaturia20.02.01.002--
Chronic obstructive pulmonary disease22.03.01.0070.007290%Not Available
Circulatory collapse24.06.02.0010.000525%Not Available
Cirrhosis alcoholic09.01.04.0050.000117%Not Available
Clavicle fracture15.08.03.010; 12.04.01.0100.000447%Not Available
Clostridium difficile colitis11.02.02.004; 07.19.01.0040.000894%Not Available
Coagulopathy01.01.02.001--Not Available
Coccidioidomycosis11.03.09.001; 22.07.08.0040.000447%Not Available
Cold sweat23.02.03.002; 08.01.03.024--Not Available
Colitis07.08.01.0010.002012%
Colitis ulcerative10.02.01.004; 07.08.01.005--Not Available
Colon cancer07.21.01.001; 16.13.01.0010.000583%Not Available
Coma17.02.09.001--Not Available
Compression fracture15.08.02.004; 12.04.02.0080.000671%Not Available
Concussion17.11.01.004; 12.01.10.0050.002012%Not Available
Confusional state19.13.01.001; 17.02.03.005--
Congenital diaphragmatic hernia07.16.01.003; 03.16.03.001; 22.09.02.0030.000117%Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
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