Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bimatoprost
Drug ID BADD_D00274
Description Bimatoprost, also known as Latisse or Lumigan, belongs to a group of drugs called prostamides, which are synthetic structural analogs of prostaglandin. Bimatoprost, marketed by Allergan, is administered in both the ophthalmic solution and implant form. It has the ability to reduce ocular hypotension, proving effective in conditions such as ocular hypertension and glaucoma.[L6877,L6892,L6898,L12069] Bimatoprost is also used to treat eyelash hypotrichosis, or sparse eyelash growth.[L6910] It was initially approved by the FDA in 2001 for ocular hypertension and later approved for hypothrichosis in 2008, as eyelash growth became a desirable adverse effect for patients using this drug.[L4894]
Indications and Usage For the reduction of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication.
Marketing Status Prescription; Discontinued
ATC Code S01EE03
DrugBank ID DB00905
KEGG ID D02724
MeSH ID D000069580
PubChem ID 5311027
TTD Drug ID D0Q2XF
NDC Product Code 72266-139; 0023-3616; 82187-1001; 68083-439; 50383-912; 71052-276; 40016-005; 24002-0021; 70069-401; 0781-6206; 65129-1206; 42571-128; 62332-511; 76397-016; 73309-002; 46144-328; 54893-0009; 57741-3000; 55679-113; 82231-102; 73309-022; 0023-3205; 60505-0583; 68180-429; 50383-908; 63190-0290; 70069-402; 68245-0004; 65035-130; 72266-140; 70069-403; 62332-507; 54245-7036; 0023-9652; 68083-295; 65727-025; 72266-241; 12079-1067; 68083-296; 38779-3066; 61556-070
Synonyms Bimatoprost | Latisse | Lumigan | AGN 192024 | 192024, AGN
Chemical Information
Molecular Formula C25H37NO4
CAS Registry Number 155206-00-1
SMILES CCNC(=O)CCCC=CCC1C(CC(C1C=CC(CCC2=CC=CC=C2)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Eyelash discolouration06.06.04.0090.005596%Not Available
Eyelash thickening06.06.04.0050.000861%Not Available
Scleral hyperaemia06.04.07.0030.005165%Not Available
Eyelid pain23.03.03.036; 06.08.03.0140.006026%Not Available
Angiopathy24.03.02.007--Not Available
Connective tissue disorder15.06.01.006--Not Available
Eyelid disorder23.03.03.028; 06.08.03.0100.003874%Not Available
Inflammation08.01.05.007--Not Available
Iris disorder06.06.06.0050.002152%Not Available
Mediastinal disorder22.09.03.001--Not Available
Motor dysfunction17.02.10.0040.000861%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Conjunctival disorder06.06.02.004--Not Available
Sensation of foreign body08.01.09.002--Not Available
Drug intolerance08.06.01.013--Not Available
Pigmentation disorder23.05.03.0010.000861%Not Available
Metabolic encephalopathy14.11.01.013; 17.13.01.0010.000861%Not Available
Urine analysis abnormal13.13.02.008--Not Available
Cystitis noninfective20.03.02.001--
Eyelash hyperpigmentation06.06.04.016; 23.05.01.010--Not Available
Eyelid exfoliation06.06.04.004; 23.03.07.0040.001722%Not Available
Dark circles under eyes08.01.03.054; 06.08.03.0190.001722%Not Available
Skin abrasion23.03.11.018; 12.01.06.0100.000861%Not Available
Ulcerative keratitis10.02.01.021; 06.04.02.0040.000861%
Macular fibrosis06.09.03.0140.000861%Not Available
Lid sulcus deepened06.09.05.0020.001291%Not Available
Medication residue present13.15.01.0320.000861%Not Available
Eyelid sensory disorder17.17.02.008; 06.01.01.0090.000861%Not Available
Trichiasis23.02.06.011; 06.06.04.0230.000861%Not Available
Congenital tricuspid valve atresia03.07.05.011; 02.07.05.0020.000861%Not Available
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