Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bimatoprost
Drug ID BADD_D00274
Description Bimatoprost, also known as Latisse or Lumigan, belongs to a group of drugs called prostamides, which are synthetic structural analogs of prostaglandin. Bimatoprost, marketed by Allergan, is administered in both the ophthalmic solution and implant form. It has the ability to reduce ocular hypotension, proving effective in conditions such as ocular hypertension and glaucoma.[L6877,L6892,L6898,L12069] Bimatoprost is also used to treat eyelash hypotrichosis, or sparse eyelash growth.[L6910] It was initially approved by the FDA in 2001 for ocular hypertension and later approved for hypothrichosis in 2008, as eyelash growth became a desirable adverse effect for patients using this drug.[L4894]
Indications and Usage For the reduction of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication.
Marketing Status Prescription; Discontinued
ATC Code S01EE03
DrugBank ID DB00905
KEGG ID D02724
MeSH ID D000069580
PubChem ID 5311027
TTD Drug ID D0Q2XF
NDC Product Code 72266-139; 0023-3616; 82187-1001; 68083-439; 50383-912; 71052-276; 40016-005; 24002-0021; 70069-401; 0781-6206; 65129-1206; 42571-128; 62332-511; 76397-016; 73309-002; 46144-328; 54893-0009; 57741-3000; 55679-113; 82231-102; 73309-022; 0023-3205; 60505-0583; 68180-429; 50383-908; 63190-0290; 70069-402; 68245-0004; 65035-130; 72266-140; 70069-403; 62332-507; 54245-7036; 0023-9652; 68083-295; 65727-025; 72266-241; 12079-1067; 68083-296; 38779-3066; 61556-070
Synonyms Bimatoprost | Latisse | Lumigan | AGN 192024 | 192024, AGN
Chemical Information
Molecular Formula C25H37NO4
CAS Registry Number 155206-00-1
SMILES CCNC(=O)CCCC=CCC1C(CC(C1C=CC(CCC2=CC=CC=C2)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Tinnitus04.04.01.002; 17.04.07.0040.001722%
Tremor17.01.06.002--
Trichorrhexis23.02.06.0070.010330%Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urine abnormality20.02.01.013--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Uveitis10.02.01.023; 06.04.03.0030.000561%
Ventricular septal defect03.07.02.001; 02.04.02.0070.000861%Not Available
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.0070.012913%
Visual acuity reduced17.17.01.011; 06.02.03.0010.003874%
Visual field defect17.17.01.001; 06.02.07.0030.003013%Not Available
Visual impairment06.02.06.0080.008178%Not Available
Vitreous floaters06.09.01.0050.001722%
Growth of eyelashes06.06.04.0070.007317%Not Available
Iris hyperpigmentation06.06.06.0010.003874%Not Available
Foreign body sensation in eyes06.01.01.0060.005596%Not Available
Madarosis23.02.02.004; 06.06.04.0100.065855%Not Available
Conjunctival hyperaemia06.04.01.0040.001291%Not Available
Eyelids pruritus23.03.12.005; 06.08.03.0070.028408%Not Available
Conjunctival bleb06.06.02.003--Not Available
Eyelid margin crusting23.03.03.029; 06.04.04.0050.004304%Not Available
Eye oedema06.08.03.013--Not Available
Eye pruritus06.04.05.0060.071020%Not Available
Ocular discomfort06.08.03.0080.006026%Not Available
Skin burning sensation23.03.03.021; 17.02.06.0090.000861%Not Available
Instillation site irritation12.07.01.013; 08.02.01.012--Not Available
Eyelid irritation23.03.04.023; 06.04.04.0070.026686%Not Available
Paranasal sinus hypersecretion22.04.06.0040.000861%Not Available
Cystoid macular oedema12.02.02.005; 06.04.06.0100.001291%Not Available
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