Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bicalutamide
Drug ID BADD_D00271
Description Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor.
Indications and Usage For treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.
Marketing Status Prescription; Discontinued
ATC Code L02BB03
DrugBank ID DB01128
KEGG ID D00961
MeSH ID C053541
PubChem ID 2375
TTD Drug ID D0V9BD
NDC Product Code 60429-177; 70518-2993; 51846-1028; 16714-816; 62559-680; 0904-6019; 16729-023; 43265-0705; 15308-0360; 54893-0001; 49711-1504; 65841-613; 43265-7195; 49711-1509; 71205-577; 68382-224; 47335-485; 63629-8308; 63759-0004; 62559-890; 53104-7664; 46014-1111; 58623-0068
Synonyms bicalutamide | 4'-cyano-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methyl-3'-(trifluoromethyl)propionanilide | Casodex | Cosudex | ICI-176334 | ICI 176334
Chemical Information
Molecular Formula C18H14F4N2O4S
CAS Registry Number 90357-06-5
SMILES CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypokalaemia14.05.03.0020.022556%
Hyponatraemia14.05.04.0020.019333%
Hypopituitarism05.03.02.0010.006444%
Hypotension24.06.03.0020.038667%
Ileus07.13.01.0010.009667%
Immune system disorder10.02.01.001--Not Available
Incontinence17.05.01.006; 07.01.06.011; 20.02.02.004--Not Available
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Influenza like illness08.01.03.0100.012889%
Injection site reaction12.07.03.015; 08.02.03.014--
Insomnia17.15.03.002; 19.02.01.002--
Interstitial lung disease22.01.02.003; 10.02.01.0330.228778%Not Available
Intestinal obstruction07.13.01.002--Not Available
Iron deficiency anaemia14.13.02.001; 01.03.01.0020.006444%Not Available
Jaundice09.01.01.004; 01.06.04.004; 23.03.03.0300.016111%Not Available
Laboratory test abnormal13.18.01.001--Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukaemia16.01.03.001; 01.10.03.0010.001681%
Leukocytosis01.02.01.0020.001681%
Leukoencephalopathy17.13.02.0030.006444%
Libido decreased21.03.02.005; 19.08.03.0010.006444%
Lipids abnormal13.12.02.0010.006444%Not Available
Liver disorder09.01.08.0010.009667%Not Available
Liver function test abnormal13.03.01.013--Not Available
Logorrhoea17.02.08.006; 19.19.02.0010.009667%Not Available
Long QT syndrome02.03.01.0170.009667%Not Available
Loss of consciousness17.02.04.004--Not Available
Loss of libido19.08.03.0030.006444%Not Available
Lung disorder22.02.07.0010.012889%Not Available
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