Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bepotastine
Drug ID BADD_D00252
Description Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor. Bepotastine was approved in Japan for use in the treatment of allergic rhinitis and uriticaria/puritus in July 2000 and January 2002, respectively, and is marketed by Tanabe Seiyaku Co., Ltd. under the brand name Talion. It is available in oral and opthalmic dosage forms in Japan. The opthalmic solution is FDA approved since Sept 8, 2009 and is under the brand name Bepreve.
Indications and Usage For the symptomatic treatment of itchy eyes (caused by IgE-induced mast cell degranulation) due to allergic conjunctivitis.
Marketing Status Not Available
ATC Code Not Available
DrugBank ID DB04890
KEGG ID D09705
MeSH ID C108476
PubChem ID 164522
TTD Drug ID D0U5VZ
NDC Product Code 42672-0100
Synonyms bepotastine | betotastine | (S)-4-(4-((4-chlorophenyl)(2-pyridil)methoxy)piperidino)butylic acid monobenzenesulfonate | betotastine besilate | TAU 284 | TAU-284
Chemical Information
Molecular Formula C21H25ClN2O3
CAS Registry Number 125602-71-3
SMILES C1CN(CCC1OC(C2=CC=C(C=C2)Cl)C3=CC=CC=N3)CCCC(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dermatitis23.03.04.002--Not Available
Dysgeusia17.02.07.003; 07.14.03.001--
Eye irritation06.04.05.003--Not Available
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Lip swelling07.05.04.005; 23.04.01.007; 10.01.05.005--Not Available
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
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