Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Benzoyl peroxide
Drug ID BADD_D00241
Description Benzoyl peroxide is a commonly used drug in topical treatments for acne.[L33249,L33264,L33269,L33299,L33314] It has been formulated as products with either a single active ingredient,[L33249,L33299] or with [erythromycin],[L33264] [clindamycin],[L33269] or [adapalene].[L33314] After administration, the peroxide bond is cleaved, allowing benzoyloxy radicals to nonspecifically interact with proteins.[A18903,A233859] This treatment decreases keratin and sebum around follicles, as well as increasing turnover of epithelial cells.[A234059,A234064,A234069] Benzoyl peroxide, in combination with erythromycin, was granted FDA approval on 26 October 1984.[L33264]
Indications and Usage Benzoyl peroxide is indicated for the treatment of mild to moderate acne vulgaris and rosacea. Combined with other agents, it may be used in the treatment of more severe acne.
Marketing Status Not Available
ATC Code D10AE01
DrugBank ID DB09096
KEGG ID D03093
MeSH ID D001585
PubChem ID 7187
TTD Drug ID D04DXN
NDC Product Code 69968-0720; 67645-342; 64760-704; 35192-017; 11410-012; 69842-646; 71397-822; 21130-730; 79481-0023; 10742-1201; 63824-438; 70707-151; 71804-852; 10812-975; 80861-003; 67645-340; 0187-0194; 70162-102; 52205-003; 71399-9234; 63550-193; 0536-1057; 69968-0043; 10742-1314; 41250-229; 49035-644; 76458-333; 47643-003; 69842-571; 11673-088; 11410-069; 0363-0137; 49825-129; 67402-021; 24470-910; 47643-001; 67645-346; 42192-162; 10742-1313; 47643-002; 11090-223; 57627-202; 70367-002; 63824-433; 10742-8304; 79903-061; 49035-132; 71295-102; 49035-646; 10742-1397; 71819-011; 76209-353; 62032-611; 71421-101; 49035-137; 71819-013; 80861-013; 71792-101; 30142-264; 67645-347; 45802-216; 52063-709; 30142-877; 68071-2307; 71687-0011; 70707-155; 58400-003; 70707-200; 62742-4093; 24470-900; 72288-525; 58400-001; 42192-161; 67645-341; 69968-0212; 70707-101; 10742-1202; 69842-081; 64760-732; 11410-066; 51531-9071; 73610-000; 11410-038; 42851-087; 70367-001; 50594-229; 0536-1351; 73921-034; 69968-0026; 69968-0164; 45802-318; 11410-046; 49035-229; 70162-103; 50544-152; 0869-0264; 73010-127; 67234-035; 11410-005; 80861-002; 72288-526; 0299-4606; 71397-821; 0869-0229; 42192-163; 10812-992; 71295-101; 39765-034; 70707-711; 73246-001; 0363-0229; 70367-004; 0316-0228; 69748-641; 69968-0033; 11410-011; 67226-2050; 68726-168; 14222-2120; 24470-901; 14222-1600; 0363-1522; 51326-111; 69842-023; 0536-1058; 51326-411; 55910-264; 67405-825; 70707-211; 76144-611; 51326-412; 10742-8356; 0536-1259; 50090-1792; 70707-212; 0187-0201; 0295-0010; 43479-105; 69842-137; 68634-068; 71399-9236; 73159-001; 68062-9109; 0536-1056; 10742-1206; 24470-909; 73350-105; 62742-4208; 69968-0653; 71804-853; 41250-348; 49527-997; 58400-009; 72288-229; 69968-0034; 76209-354; 0536-1129; 10742-1301; 69842-637; 0536-1055; 59958-401; 10742-8355; 50090-1720; 71131-100; 45802-280; 70367-009; 58232-0219; 71804-230; 10742-1205; 42546-016; 11410-060; 11410-040; 10738-034; 68723-305; 73921-031; 69968-0684; 55621-017; 69968-0032; 63940-063; 65113-2373; 72288-264; 10742-8354; 51927-3085; 72957-001; 11410-002; 56152-4009; 71817-858; 35573-453; 10742-8293; 17129-002; 71399-9474; 49967-076; 80861-010; 0363-0467; 45802-308; 35573-454; 79481-0022; 64760-712; 68071-4393; 67645-344; 49967-238; 56152-4012; 73921-032; 24470-911; 0363-0264; 49035-264; 68062-9107; 10742-1203; 73921-033; 65113-2372; 76144-610; 69968-0291; 0316-0227; 50544-150; 41250-264; 50066-052; 24470-902; 41250-347; 77924-002; 67645-343; 71399-9478; 14222-1610; 67405-835; 80861-006; 14222-1620; 73010-900; 70764-107; 50544-151; 11822-6184; 68343-123; 70707-152; 59958-402; 69842-076; 51326-112; 10742-8353; 63824-437; 71421-102; 62742-4092; 67645-345; 62742-4212; 72811-137; 0536-1261; 10742-8397; 45802-101; 70764-106; 49035-829; 62742-4075; 67405-830
Synonyms Benzoyl Peroxide | Peroxide, Benzoyl | Diphenylglyoxal Superoxide | Superoxide, Diphenylglyoxal | Benzoyl Superoxide | Superoxide, Benzoyl | Dibenzoyl Peroxide | Peroxide, Dibenzoyl | PanOxyl
Chemical Information
Molecular Formula C14H10O4
CAS Registry Number 94-36-0
SMILES C1=CC=C(C=C1)C(=O)OOC(=O)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Application site erythema23.03.06.005; 12.07.01.001; 08.02.01.001--Not Available
Application site rash12.07.01.016; 08.02.01.016; 23.03.13.008--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Dry skin23.03.03.001--
Erythema23.03.06.001--Not Available
Hypersensitivity10.01.03.003--
Immune system disorder10.02.01.001--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Pain08.01.08.004--
Pruritus23.03.12.001--
Skin disorder23.03.03.007--Not Available
Skin exfoliation23.03.07.003--Not Available
Skin irritation23.03.04.009--Not Available
Application site discolouration23.03.03.023; 12.07.01.030; 08.02.01.030--Not Available
Application site hypersensitivity12.07.01.014; 10.01.03.009; 08.02.01.013--Not Available
Sensitisation08.01.05.009; 10.02.01.012--Not Available
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