Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Benzocaine
Drug ID BADD_D00237
Description Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.[A231219] It is commonly used for local anesthesia in many over the counter products.[L32454,L32459,L32464] Benzocaine was first used for local anesthesia in dentistry.[A231259]
Indications and Usage For general use as a lubricant and topical anesthetic on esophagus, larynx, mouth, nasal cavity, rectum, respiratory tract or trachea, urinary tract, vagina. It is also used to suppress gag reflex.
Marketing Status Not Available
ATC Code C05AD03; D02BA01; D04AB04; N01BA05; R02AD01
DrugBank ID DB01086
KEGG ID D00552
MeSH ID D001566
PubChem ID 2337
TTD Drug ID D0Q8ZX
NDC Product Code 52642-036; 68400-351; 24794-220; 0283-0920; 73288-004; 55346-2904; 44224-0102; 37946-5824; 66184-161; 69498-005; 71363-101; 67234-038; 64522-001; 69745-062; 24794-224; 64522-004; 37808-691; 0283-0293; 66467-4004; 69484-001; 50804-025; 67659-410; 42961-401; 52412-350; 25047-753; 69745-060; 0395-9105; 59779-644; 62991-1021; 42756-1107; 69745-064; 55910-065; 66975-355; 11822-1616; 24794-221; 71363-103; 69483-005; 53045-136; 68400-357; 49964-0050; 0283-1886; 63736-378; 67091-198; 60630-077; 0283-0569; 0283-1116; 0283-0871; 42756-1105; 42756-1109; 43498-310; 68987-002; 71363-100; 64090-0010; 59779-743; 11822-0613; 66184-156; 61010-8100; 0283-0998; 0404-0036; 0283-0914; 63736-040; 55346-2901; 69510-358; 68400-478; 61509-101; 69484-005; 69509-004; 51927-1194; 0283-1016; 66357-020; 51927-0060; 69634-026; 0404-0037; 68421-8100; 0283-0520; 68987-006; 53045-144; 50486-550; 68400-461; 66975-353; 69509-007; 63736-375; 0699-7001; 69842-358; 61509-103; 69745-063; 69524-555; 59779-830; 50804-191; 80070-220; 0404-0033; 71922-104; 69301-002; 41163-021; 68400-353; 0699-7051; 50227-1007; 53045-130; 54723-722; 68400-358; 50332-0050; 69634-021; 0283-0886; 69509-001; 0404-0034; 71922-100; 53045-137; 63029-531; 53045-135; 11822-6170; 10237-200; 71814-410; 59779-545; 53045-147; 53045-142; 69509-009; 36800-389; 69004-005; 11822-0345; 55910-066; 49354-375; 55670-956; 42756-1106; 68987-001; 72484-433; 59779-582; 69510-352; 43128-033; 76523-068; 69301-001; 69004-006; 53045-133; 69483-009; 68400-323; 43128-034; 71363-106; 71687-1053; 69842-377; 69509-006; 69484-006; 71922-101; 72667-019; 25047-754; 79903-042; 41520-043; 43498-311; 81999-0002; 70721-006; 48201-012; 36800-836; 76523-069; 0699-7061; 66184-155; 37808-116; 69842-693; 42961-810; 69729-018; 55636-000; 38779-0063; 69626-0049; 70721-007; 70721-003; 71922-105; 49452-0971; 45591-002; 67777-405; 49354-353; 0283-1820; 46122-653; 69842-381; 61509-104; 63941-047; 70742-180; 69634-023; 63240-5100; 61876-0721; 0404-0035; 69498-001; 54723-006; 68987-004; 70721-005; 69301-006; 68987-003; 71052-673; 55670-810; 11822-0614; 46414-2040; 76523-063; 66975-358; 63736-041; 69745-065; 71347-105; 66975-357; 55346-2902; 67172-017; 69634-027; 54723-003; 55910-660; 71363-104; 65923-094; 58593-781; 43128-032; 66467-4001; 43498-317; 71363-105; 24794-225; 69550-324; 50227-1010; 69483-001; 0404-0018; 68400-359; 69842-660; 67239-0221; 53045-141; 24794-223; 69004-003; 70000-0554; 66467-4002; 69509-003; 68987-005; 60640-2000; 53045-140; 71347-102; 67172-018; 0363-5337; 53045-145; 59779-444; 70721-004; 0283-0220; 80070-230; 53045-146; 59779-913; 0363-6008; 43128-031; 0924-5203; 43498-316; 35418-010; 11822-0043; 64522-003; 53045-138; 70897-004; 43498-314; 69509-008; 49452-0972; 68400-352; 73118-004; 50227-1009; 43498-312; 50227-1002; 69301-003; 55346-2903; 68400-459; 36800-624; 67239-0223; 76523-062; 60640-9400; 61509-105; 69237-001; 20362-0001; 0924-5201; 69842-642; 69510-353; 11822-0316; 70000-0553; 0404-0039; 60640-1700; 72751-0302; 50227-1004; 66975-352; 69004-001; 49035-569; 69510-351; 25047-752; 70721-009; 11822-6035; 69498-006; 71922-103; 69484-002; 11527-061; 71363-107; 50814-038; 10237-709; 68400-508; 68400-479; 67239-0222; 69004-002; 68400-354; 65517-0005; 30142-212; 42756-1103; 69509-002; 69509-005; 69301-005; 66467-4006; 67239-0219; 0363-1079; 11822-5340; 42756-1104; 70742-182; 69842-167
Synonyms Benzocaine | 4-Aminobenzoic Acid Ethyl Ester | Bensokain | Ethyl Aminobenzoate | Anaesthesin | Anesthesin | Benzocaine Hydrobromide | Hydrobromide, Benzocaine | Benzocaine Hydrochloride | Hydrochloride, Benzocaine | Benzocaine Acetate | Acetate, Benzocaine | Benzocaine Methanesulfonate | Methanesulfonate, Benzocaine | Ethoform | Americaine | Benzocaine Formate | Formate, Benzocaine
Chemical Information
Molecular Formula C9H11NO2
CAS Registry Number 94-09-7
SMILES CCOC(=O)C1=CC=C(C=C1)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.002--
Dermatitis23.03.04.002--Not Available
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Dyspnoea22.02.01.004; 02.01.03.002--
Erythema23.03.06.001--Not Available
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Methaemoglobinaemia01.05.01.002--
Nausea07.01.07.001--
Oedema08.01.07.006; 14.05.06.010--Not Available
Oral discomfort07.05.05.001--Not Available
Oral pain07.05.03.002--
Pain08.01.08.004--
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Respiratory distress22.02.01.012--Not Available
Skin irritation23.03.04.009--Not Available
Swelling08.01.03.015--Not Available
Tenderness08.01.08.005--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
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