Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Benazepril
Drug ID BADD_D00227
Description Benazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure[A838,A837]. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor[A836].
Indications and Usage For the treatment of hypertension. It may be used alone or in combination with thiazide diuretics.
Marketing Status Prescription; Discontinued
ATC Code C09AA07
DrugBank ID DB00542
KEGG ID D07499
MeSH ID C044946
PubChem ID 5362124
TTD Drug ID D0U3EC
NDC Product Code 61919-739
Synonyms benazepril | benazapril | benzazepril | Labopal | Lotensin | Cibacène | Cibacen | Briem | benazepril hydrochloride | CGS-14824-A | CGS-14824A
Chemical Information
Molecular Formula C24H28N2O5
CAS Registry Number 86541-75-5
SMILES CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.0010.000316%
Alanine aminotransferase increased13.03.01.0030.000474%
Alopecia23.02.02.001--
Angioedema23.04.01.001; 10.01.05.0090.001106%Not Available
Anxiety19.06.02.002--
Arrhythmia02.03.02.0010.000632%Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Aspartate aminotransferase increased13.03.01.0060.000316%
Asthenia08.01.01.0010.000632%Not Available
Asthma10.01.03.010; 22.03.01.002--Not Available
Atrial fibrillation02.03.03.0020.000474%
Bilirubin conjugated increased13.03.01.0070.000316%Not Available
Blood bilirubin increased13.03.01.0080.000316%
Blood pressure increased13.14.03.0050.000948%Not Available
Blood pressure systolic increased13.14.03.0060.000474%Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Cerebral infarction24.04.06.002; 17.08.01.0040.000474%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.000632%Not Available
Cold sweat23.02.03.002; 08.01.03.0240.000316%Not Available
Completed suicide08.04.01.010; 19.12.01.0010.000082%Not Available
Constipation07.02.02.001--
Cough22.02.03.0010.002686%
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.001580%
Dizziness postural24.06.02.008; 17.02.05.004; 02.01.02.005--Not Available
Drug hypersensitivity10.01.01.0010.000948%Not Available
Dyspnoea22.02.01.004; 02.01.03.0020.000790%
Electrocardiogram abnormal13.14.05.001--Not Available
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