Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Azithromycin
Drug ID BADD_D00203
Description Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration [A174172]. It was initially approved by the FDA in 1991 [A174175]. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually transmitted and enteric infections. It is structurally related to erythromycin [A174169]. Azithromycin [9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin] is a part of the _azalide_ subclass of macrolides, and contains a 15-membered ring, with a methyl-substituted nitrogen instead of a carbonyl group at the 9a position on the aglycone ring, which allows for the prevention of its metabolism. This differentiates azithromycin from other types of macrolides [A174175]. In March 2020, a small study was funded by the French government to investigate the treatment of COVID-19 with a combination of azithromycin and the anti-malaria drug [hydroxychloroquine]. The results were positive, all patients taking the combination were virologically cured within 6 days of treatment, however, larger studies are required.[A192546]
Indications and Usage For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions: H. influenzae, M. catarrhalis, S. pneumoniae, C. pneumoniae, M. pneumoniae, S. pyogenes, S. aureus, S. agal
Marketing Status Prescription; Discontinued
ATC Code J01FA10; S01AA26
DrugBank ID DB00207
KEGG ID D06390
MeSH ID D017963
PubChem ID 447043
TTD Drug ID D03HJK
NDC Product Code 53002-0470; 50111-787; 68071-2672; 70710-1458; 53002-5228; 68071-4795; 0781-5789; 68788-8125; 70518-2708; 50090-4720; 71610-001; 0409-0144; 50090-2509; 62332-251; 63629-8034; 68071-1528; 63629-7784; 63629-8251; 50090-4458; 68071-4773; 59651-008; 16571-695; 42806-147; 70710-1457; 59762-3051; 55150-174; 68788-7659; 71205-196; 50090-4721; 70518-0713; 68071-4902; 55700-731; 65862-641; 24658-706; 72189-314; 70518-2562; 50090-5376; 68071-4785; 63187-189; 76420-006; 0093-2027; 0781-5793; 53002-6221; 68071-4786; 53002-2230; 70518-3217; 71205-158; 70771-1424; 68071-4711; 71205-503; 50090-5283; 42291-082; 64679-961; 71205-645; 63187-169; 63187-594; 64679-964; 68788-8124; 65862-642; 42291-084; 55695-002; 71205-253; 70518-2433; 68788-7549; 68071-2507; 76420-213; 71205-519; 53002-2228; 68788-7066; 68071-4779; 63187-093; 63629-8311; 61294-9990; 59762-3130; 69306-250; 68071-4364; 42291-083; 0781-8089; 71610-381; 61919-555; 59651-007; 68071-2543; 53002-2225; 50090-5366; 68071-5035; 42806-151; 50111-788; 62332-253; 46708-253; 69452-173; 64679-962; 59762-3140; 70518-3254; 68071-2297; 45865-536; 60760-502; 68788-7598; 50090-0984; 63187-007; 59762-3120; 68071-5058; 68071-4812; 71335-1755; 69452-172; 71205-216; 68071-1527; 68788-7307; 68071-4774; 53002-2231; 68788-7507; 63187-622; 0093-2026; 71205-021; 50090-0983; 60760-808; 68071-5238; 43386-471; 42806-149; 71335-1252; 16571-696; 70710-1460; 50111-789; 53002-2224; 71205-424; 62756-512; 24658-708; 72189-088; 38779-2246; 59762-2198; 72189-087; 68071-5082; 59762-3110; 70518-0784; 55700-784; 42806-150; 69452-171; 50090-2491; 72189-093; 55700-852; 70710-1459; 0781-8090; 0781-8091; 68071-2266; 70771-1425; 46708-058; 53002-5221; 70518-3169; 70771-1422; 70518-0599; 53002-0473; 70771-1423; 65427-310; 68071-5170; 68071-2622; 53002-0472; 68071-2529; 71335-1195; 62332-252; 72189-015; 68788-7636; 63187-604; 68071-4255; 68071-4976; 46708-057; 55695-003; 71205-566; 43386-470
Synonyms Azithromycin | Azythromycin | Sumamed | Toraseptol | Vinzam | CP-62993 | CP 62993 | CP62993 | Zithromax | Azitrocin | Azadose | Ultreon | Zitromax | Azithromycin Dihydrate | Dihydrate, Azithromycin | Azithromycin Monohydrate | Monohydrate, Azithromycin | Goxal | Zentavion
Chemical Information
Molecular Formula C38H72N2O12
CAS Registry Number 83905-01-5
SMILES CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C) C)O)(C)O)C)C)C)O)(C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Basophil count increased13.01.06.002--Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Blood bicarbonate increased13.11.01.001--Not Available
Blood bilirubin increased13.03.01.0080.000025%
Blood creatine phosphokinase increased13.04.01.001--
Blood creatinine increased13.13.01.004--
Blood glucose decreased13.02.02.001--Not Available
Blood glucose increased13.02.02.002--Not Available
Blood lactate dehydrogenase increased13.04.02.002--
Blood potassium decreased13.11.01.010--Not Available
Blood potassium increased13.11.01.011--Not Available
Blood pressure abnormal13.14.03.0010.000025%Not Available
Blood pressure decreased13.14.03.002--Not Available
Blood sodium decreased13.11.01.012--Not Available
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Breast feeding26.05.01.001--Not Available
Bronchospasm10.01.03.012; 22.03.01.0040.000025%
Burning sensation17.02.06.001; 08.01.09.0290.000038%Not Available
C-reactive protein increased13.09.01.0070.000025%Not Available
Cardiac arrest02.03.04.0010.000026%
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardio-respiratory arrest02.03.04.002; 22.02.06.007--Not Available
Cardiomegaly02.04.02.0010.000010%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chalazion06.04.04.0020.000025%Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.000050%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
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